A multi-stimuli responsive, self-assembling, boronic acid dipeptide

A multi-stimuli responsive, self-assembling, boronic acid dipeptide

Modification of the dipeptide of phenylalanine, FF, with a boronic acid (BA) functionality imparts unique aqueous self-assembly behavior that responds to multiple stimuli. Changes in pH and ionic strength are used to trigger hydrogelation via the formation of nanoribbon networks. Furthermore, we sho...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-10, Vol.51 (77), p.14532-14535
Hauptverfasser: Jones, Brad H, Martinez, Alina M, Wheeler, Jill S, McKenzie, Bonnie B, Miller, Lance L, Wheeler, David R, Spoerke, Erik D
Format: Artikel
Sprache:eng
Schlagworte:
Binding
Boronic Acids - chemistry
Dipeptides - chemistry
Dismantling
Hydrogen-Ion Concentration
Nanostructure
Networks
Osmolar Concentration
Phenylalanine
Polyols
Self assembly
Stimuli
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Beschreibung
Zusammenfassung:Modification of the dipeptide of phenylalanine, FF, with a boronic acid (BA) functionality imparts unique aqueous self-assembly behavior that responds to multiple stimuli. Changes in pH and ionic strength are used to trigger hydrogelation via the formation of nanoribbon networks. Furthermore, we show for the first time that the binding of polyols to the BA functionality can modulate a peptide between its assembled and disassembled states.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05207f