Proneurotrophin Binding to P75 Neurotrophin Receptor (P75ntr) Is Essential for Brain Lesion Formation and Functional Impairment after Experimental Traumatic Brain Injury

Traumatic brain injury (TBI) initiates an excessive mediator release of e.g. neurotrophins, which promote neuronal survival, differentiation, and modulate synaptic plasticity. Paradoxically, mature forms of neurotrophins promote neuronal survival, whereas unprocessed forms of neurotrophins induce ce...

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Veröffentlicht in:	Journal of neurotrauma 2015-10, Vol.32 (20), p.1599-1607
Hauptverfasser:	Sebastiani, Anne, Gölz, Christina, Werner, Christian, Schäfer, Michael K E, Engelhard, Kristin, Thal, Serge C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesiology Animals Behavior, Animal Brain damage Brain Injuries - drug therapy Brain Injuries - metabolism Brain Injuries - pathology Brain Injuries - physiopathology Brain-derived neurotrophic factor Cell death Cell Death - drug effects Cytokines Disease Models, Animal Experiments Female Kinases Male Mice Mice, Inbred C57BL Mice, Knockout Protein Binding Receptors, Nerve Growth Factor - antagonists & inhibitors Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects Trauma Traumatic brain injury Tumor necrosis factor-TNF
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