Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial

IMPORTANCE: Agitation is common among patients with Alzheimer disease; safe, effective treatments are lacking. OBJECTIVE: To assess the efficacy, safety, and tolerability of dextromethorphan hydrobromide–quinidine sulfate for Alzheimer disease–related agitation. DESIGN, SETTING, AND PARTICIPANTS: Ph...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2015-09, Vol.314 (12), p.1242-1254
Hauptverfasser:	Cummings, Jeffrey L, Lyketsos, Constantine G, Peskind, Elaine R, Porsteinsson, Anton P, Mintzer, Jacobo E, Scharre, Douglas W, De La Gandara, Jose E, Agronin, Marc, Davis, Charles S, Nguyen, Uyen, Shin, Paul, Tariot, Pierre N, Siffert, João
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aggression - drug effects Alzheimer Disease - complications Alzheimer's disease Clinical outcomes Dementia Dextromethorphan - adverse effects Dextromethorphan - therapeutic use Double-Blind Method Drug Combinations Female Humans Male Middle Aged Patient safety Placebos - administration & dosage Psychomotor Agitation - drug therapy Quinidine - adverse effects Quinidine - therapeutic use Treatment Outcome
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