Effect of Bisecting GlcNAc and Core Fucosylation on Conformational Properties of Biantennary Complex-Type N-Glycans in Solution

The introduction of bisecting GlcNAc and core fucosylation in N-glycans is essential for fine functional regulation of glycoproteins. In this paper, the effect of these modifications on the conformational properties of N-glycans is examined at the atomic level by performing replica-exchange molecula...

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Veröffentlicht in:	The journal of physical chemistry. B 2012-07, Vol.116 (29), p.8504-8512
Hauptverfasser:	Nishima, Wataru, Miyashita, Naoyuki, Yamaguchi, Yoshiki, Sugita, Yuji, Re, Suyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - chemistry Carbohydrate Conformation Carbohydrate Sequence Constants Control Flexibility Fucose Fucose - chemistry Hydrogen Bonding Mathematical models Molecular Dynamics Simulation Molecular Sequence Data Polysaccharides - chemistry Sampling Scalars Simulation
Online-Zugang:	Volltext
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