Activation of a silent phenazine biosynthetic gene cluster reveals a novel natural product and a new resistance mechanism against phenazines

The activation of silent biosynthetic gene clusters is a principal challenge for genome mining strategies in drug discovery. In the present study, a phenazine biosynthetic gene cluster was discovered in the Gram-positive bacterium Streptomyces tendaeTue1028. This gene cluster remained silent under a...

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Veröffentlicht in:	MedChemComm 2012-08, Vol.3 (8), p.1009-1019
Hauptverfasser:	Saleh, Orwah, Bonitz, Tobias, Flinspach, Katrin, Kulik, Andreas, Burkard, Nadja, Mühlenweg, Agnes, Vente, Andreas, Polnick, Stefan, Lämmerhofer, Michael, Gust, Bertolt, Fiedler, Hans-Peter, Heide, Lutz
Format:	Artikel
Sprache:	eng
Schlagworte:	Streptomyces
Online-Zugang:	Volltext
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