Lack of non-hematological cross intolerance of dasatinib to imatinib in imatinib-intolerant patients with Philadelphia chromosome positive chronic myeloid leukemia or acute lymphatic leukemia: a retrospective safety analysis

The aim of this retrospective study was to evaluate the toxicity profiles of dasatinib in patients with Philadelphia chromosome positive chronic myeloid leukemia (CML) or acute lymphatic leukemia (ALL) who were intolerant to imatinib, and who had been enrolled in our previous clinical trials to eval...

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Veröffentlicht in:	International journal of hematology 2011-06, Vol.93 (6), p.745-749
Hauptverfasser:	Kobayashi, Yukio, Sakamaki, Hisashi, Fujisawa, Shin, Ando, Kiyoshi, Yamamoto, Kazuhito, Okada, Masaya, Ishizawa, Kenichi, Nagai, Tadashi, Miyawaki, Syuichi, Motoji, Toshiko, Usui, Noriko, Iida, Shinsuke, Taniwaki, Masafumi, Uoshima, Nobuhiko, Seriu, Taku, Ohno, Ryuzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Benzamides Biological and medical sciences Dasatinib Drug toxicity and drugs side effects treatment Hematologic and hematopoietic diseases Hematologic Diseases - etiology Hematology Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medicine Medicine & Public Health Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Oncology Original Article Pharmacology. Drug treatments Piperazines - administration & dosage Piperazines - adverse effects Piperazines - therapeutic use Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrimidines - therapeutic use Retrospective Studies Thiazoles - administration & dosage Thiazoles - adverse effects Thiazoles - therapeutic use
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