Development of vaccines for Plasmodium vivax malaria
Abstract Plasmodium vivax continues to cause significant morbidity outside Africa with more than 50% of malaria cases in many parts of South and South-east Asia, Pacific islands, Central and South America being attributed to P. vivax infections. The unique biology of P. vivax , including its ability...
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| Veröffentlicht in: | Vaccine 2015-12, Vol.33 (52), p.7489-7495 |
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| creator | Mueller, Ivo Shakri, Ahmad Rushdi Chitnis, Chetan E |
| description | Abstract Plasmodium vivax continues to cause significant morbidity outside Africa with more than 50% of malaria cases in many parts of South and South-east Asia, Pacific islands, Central and South America being attributed to P. vivax infections. The unique biology of P. vivax , including its ability to form latent hypnozoites that emerge months to years later to cause blood stage infections, early appearance of gametocytes before clinical symptoms are apparent and a shorter development cycle in the vector makes elimination of P. vivax using standard control tools difficult. The availability of an effective vaccine that provides protection and prevents transmission would be a valuable tool in efforts to eliminate P. vivax . Here, we review the latest developments related to P. vivax malaria vaccines and discuss the challenges as well as directions toward the goal of developing highly efficacious vaccines against P. vivax malaria. |
| doi_str_mv | 10.1016/j.vaccine.2015.09.060 |
| format | Article |
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The unique biology of P. vivax , including its ability to form latent hypnozoites that emerge months to years later to cause blood stage infections, early appearance of gametocytes before clinical symptoms are apparent and a shorter development cycle in the vector makes elimination of P. vivax using standard control tools difficult. The availability of an effective vaccine that provides protection and prevents transmission would be a valuable tool in efforts to eliminate P. vivax . Here, we review the latest developments related to P. vivax malaria vaccines and discuss the challenges as well as directions toward the goal of developing highly efficacious vaccines against P. vivax malaria.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2015.09.060</identifier><identifier>PMID: 26428453</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Africa ; Allergy and Immunology ; Biomedical Research ; Blood stage malaria vaccines ; Drug dosages ; Drug resistance ; Government agencies ; Humans ; Immunity to malaria ; Infections ; Life Cycle Stages - immunology ; Liver ; Malaria ; Malaria vaccines ; Malaria Vaccines - immunology ; Malaria, Vivax - immunology ; Malaria, Vivax - prevention & control ; Malaria, Vivax - transmission ; Mosquitoes ; P. vivax malaria ; Pacific Islands ; Parasitic diseases ; Plasmodium vivax ; Plasmodium vivax - immunology ; Plasmodium vivax - physiology ; Pre-erythrocytic stage malaria vaccines ; Prevention ; Proteins ; South America ; Transmission blocking malaria vaccines ; Vaccines ; Vector-borne diseases ; Vectors (Biology)</subject><ispartof>Vaccine, 2015-12, Vol.33 (52), p.7489-7495</ispartof><rights>2015</rights><rights>Copyright © 2015. 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The unique biology of P. vivax , including its ability to form latent hypnozoites that emerge months to years later to cause blood stage infections, early appearance of gametocytes before clinical symptoms are apparent and a shorter development cycle in the vector makes elimination of P. vivax using standard control tools difficult. The availability of an effective vaccine that provides protection and prevents transmission would be a valuable tool in efforts to eliminate P. vivax . Here, we review the latest developments related to P. vivax malaria vaccines and discuss the challenges as well as directions toward the goal of developing highly efficacious vaccines against P. vivax malaria.</description><subject>Africa</subject><subject>Allergy and Immunology</subject><subject>Biomedical Research</subject><subject>Blood stage malaria vaccines</subject><subject>Drug dosages</subject><subject>Drug resistance</subject><subject>Government agencies</subject><subject>Humans</subject><subject>Immunity to malaria</subject><subject>Infections</subject><subject>Life Cycle Stages - immunology</subject><subject>Liver</subject><subject>Malaria</subject><subject>Malaria vaccines</subject><subject>Malaria Vaccines - immunology</subject><subject>Malaria, Vivax - immunology</subject><subject>Malaria, Vivax - prevention & control</subject><subject>Malaria, Vivax - transmission</subject><subject>Mosquitoes</subject><subject>P. vivax malaria</subject><subject>Pacific Islands</subject><subject>Parasitic diseases</subject><subject>Plasmodium vivax</subject><subject>Plasmodium vivax - immunology</subject><subject>Plasmodium vivax - physiology</subject><subject>Pre-erythrocytic stage malaria vaccines</subject><subject>Prevention</subject><subject>Proteins</subject><subject>South America</subject><subject>Transmission blocking malaria vaccines</subject><subject>Vaccines</subject><subject>Vector-borne diseases</subject><subject>Vectors (Biology)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk2L1EAQhhtR3HH1JygBL14Su_ornYuyrJ-woKCCt6a2U4Eek_TYPQnuv7fHGRX2oqeC4qm3qPctxh4Db4CDeb5tVvQ-zNQIDrrhXcMNv8M2YFtZCw32LttwYVStgH89Yw9y3nLOtYTuPjsrfWGVlhumXtFKY9xNNO-rOFQn0VwNMVUfR8xT7MMyVWtY8Uc14Ygp4EN2b8Ax06NTPWdf3rz-fPmuvvrw9v3lxVXttbD7uuekjBo0grJIhoxRKK572_KBWhwsaVu2SbACrdUCJYI1UrWdl_1gTS_P2bOj7i7F7wvlvZtC9jSOOFNcsoNWS2UMCPE_KEBn2k4X9OktdBuXNJdDfgm2UnWtLZQ-Uj7FnBMNbpfChOnGAXeHBNzWncxyhwQc71xJoMw9Oakv1xP1f6Z-W16Al0eAinNroOSyDzR76kMiv3d9DP9c8eKWgh_DHDyO3-iG8t9rXBaOu0-HNzh8AWgOUhotfwJHDKyl</recordid><startdate>20151222</startdate><enddate>20151222</enddate><creator>Mueller, Ivo</creator><creator>Shakri, Ahmad Rushdi</creator><creator>Chitnis, Chetan E</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20151222</creationdate><title>Development of vaccines for Plasmodium vivax malaria</title><author>Mueller, Ivo ; Shakri, Ahmad Rushdi ; Chitnis, Chetan E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-d0e464f5a148ae6e664a2bd870fe7af8e58acc3182a8852a3a1863479c3df86d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Africa</topic><topic>Allergy and Immunology</topic><topic>Biomedical Research</topic><topic>Blood stage malaria vaccines</topic><topic>Drug dosages</topic><topic>Drug resistance</topic><topic>Government agencies</topic><topic>Humans</topic><topic>Immunity to malaria</topic><topic>Infections</topic><topic>Life Cycle Stages - 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| ispartof | Vaccine, 2015-12, Vol.33 (52), p.7489-7495 |
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| subjects | Africa Allergy and Immunology Biomedical Research Blood stage malaria vaccines Drug dosages Drug resistance Government agencies Humans Immunity to malaria Infections Life Cycle Stages - immunology Liver Malaria Malaria vaccines Malaria Vaccines - immunology Malaria, Vivax - immunology Malaria, Vivax - prevention & control Malaria, Vivax - transmission Mosquitoes P. vivax malaria Pacific Islands Parasitic diseases Plasmodium vivax Plasmodium vivax - immunology Plasmodium vivax - physiology Pre-erythrocytic stage malaria vaccines Prevention Proteins South America Transmission blocking malaria vaccines Vaccines Vector-borne diseases Vectors (Biology) |
| title | Development of vaccines for Plasmodium vivax malaria |
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