Under-recognized complications in patients with paroxysmal nocturnal haemoglobinuria: raised pulmonary pressure and reduced right ventricular function

Summary Pulmonary hypertension is becoming a recognized complication of the hereditary and acquired haemolytic anaemias, associated with a poor prognosis. Recently we reported that patients with paroxysmal nocturnal haemoglobinuria (PNH) have high levels of N‐terminal pro‐brain natriuretic peptide (...

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Veröffentlicht in:	British journal of haematology 2012-08, Vol.158 (3), p.409-414
Hauptverfasser:	Hill, Anita, Sapsford, Robert J., Scally, Andrew, Kelly, Richard, Richards, Stephen J., Khurisgara, Gus, Sivananthan, Mohan U., Hillmen, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anemias. Hemoglobinopathies Biological and medical sciences Diseases of red blood cells Doppler-estimated systolic pulmonary hypertension Echocardiography, Doppler endogenous nitrate vasodilator haemolysis Heart - physiopathology Hematologic and hematopoietic diseases Hemoglobinuria, Paroxysmal - blood Hemoglobinuria, Paroxysmal - complications Hemoglobinuria, Paroxysmal - physiopathology Humans Hypertension, Pulmonary - blood Hypertension, Pulmonary - complications Hypertension, Pulmonary - physiopathology Medical sciences Middle Aged Natriuretic Peptide, Brain - blood paroxysmal nocturnal haemoglobinuria Peptide Fragments - blood Pneumology pulmonary hypertension Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Ventricular Function, Right - physiology Young Adult
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