P105 Biliary drainage in a rat: a long-term continuous drainage model resulting in liver damage and an altered FXR pathway, lipid and cholesterol metabolism

IntroductionWe hypothesised that the development of intestinal failure associated liver disease (IFALD) caused by an enterocutaneous fistula in which the enterohepatic circulation is interrupted without obstructive cholestasis leads to reduced farnosoid X receptor (FXR) signalling, ultimately leadin...

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Veröffentlicht in:	Gut 2011-09, Vol.60 (Suppl 2), p.A48-A49
Hauptverfasser:	Koelfat, K V K, Visschers, R G J, Hodin, C M, Shiri-Sverdlov, R, Buurman, W A, Lenaerts, K, Damink, S W M O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Bile Bile ducts Bilirubin Cannulation Cholestasis Cholesterol Fatty acids Fatty-acid synthase Fibrosis Fistulae Gangrene Hydroxymethylglutaryl-CoA reductase Inflammation Intestine Lipid metabolism Lipids Liver Liver diseases Long-term effects Metabolism Necrosis Peroxisome proliferator-activated receptors Rodents Signal transduction Steatosis Therapeutic applications Wound drainage
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