The clinical impact of platelet-rich plasma on tendinopathy compared to placebo or dry needling injections: A meta-analysis
Abstract Objective The purpose of this meta-analysis was to compare the impact of platelet-rich plasma with that of placebo or dry needling injections on tendinopathy. Methods The databases of PubMed, CENTRAL, Scopus, Web of Science, and trial registries, reference lists, and conference abstract boo...
Gespeichert in:
| Veröffentlicht in: | Physical therapy in sport 2016-01, Vol.17, p.87-94 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 94 |
|---|---|
| container_issue | |
| container_start_page | 87 |
| container_title | Physical therapy in sport |
| container_volume | 17 |
| creator | Tsikopoulos, Konstantinos Tsikopoulos, Ioannis Simeonidis, Evangelos Papathanasiou, Efthymia Haidich, Anna-Bettina Anastasopoulos, Nikolaos Natsis, Konstantinos |
| description | Abstract Objective The purpose of this meta-analysis was to compare the impact of platelet-rich plasma with that of placebo or dry needling injections on tendinopathy. Methods The databases of PubMed, CENTRAL, Scopus, Web of Science, and trial registries, reference lists, and conference abstract books were searched up to December 2014. Adults with tendinopathy in randomized controlled trials were enrolled. The trials compared effect of platelet-rich plasma with that of placebo or dry needling. We used subgroup analysis linked to the anatomical location of the tendinopathy. The primary outcome was pain intensity at two or three and six months after intervention. The secondary outcome was functional disability at three months after treatment. Results Five trials were included. There was a statistically significant difference in favor of the platelet-rich plasma intervention at the second primary outcome time point (SMD −0.48, 95%CIs −0.86 to −0.10, I2 = 0%, p = 0.01) and at the secondary outcome time point (SMD −0.47, 95%CIs −0.85 to −0.09, I2 = 0%, p=0.01). Conclusions Platelet-rich plasma did not provide significantly greater clinical benefit versus placebo or dry needling for the treatment of tendinopathy at a six-month follow-up. However, there was a marginal clinical difference in favor of platelet-rich plasma injections on rotator cuff tendinopathy. |
| doi_str_mv | 10.1016/j.ptsp.2015.06.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1753459892</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1466853X15000437</els_id><sourcerecordid>1751196643</sourcerecordid><originalsourceid>FETCH-LOGICAL-c608t-ae0b05b55dddc085dba3e99d74ca0bfdba315f461703a6f4b3178bfb26a309843</originalsourceid><addsrcrecordid>eNqNkl2L1TAQhoso7of-AS8k4I03rZOmSVsRYVnWD1jwwhW8C2ky9eTYJjXJEYp_3pSzq7AX4lUyzDMvzLxvUTyjUFGg4tW-WlJcqhoor0BUAOxBcUq7lpVUADzM_0aIsuPs60lxFuMegOYGe1yc1ELUtK6b0-LXzQ6JnqyzWk3EzovSifiRLJNKOGEqg9W7rYqzIt6RhM5Y5xeVdivRPvMBDUl-QzQOnvhATFiJQzRZ9Ruxbo86We_ia3JBZkyqVE5Na7TxSfFoVFPEp7fvefHl3dXN5Yfy-tP7j5cX16UW0KVSIQzAB86NMRo6bgbFsO9N22gFw7iVlI-NoC0wJcZmYLTthnGohWLQdw07L14edZfgfxwwJjnbqHGalEN_iJK2nDW87_r6f1BKeyEaltEX99C9P4S82lGQ95DBTNVHSgcfY8BRLsHOKqySgtxclHu5uSg3FyUImV3MQ89vpQ_DjObPyJ1tGXhzBDCf7afFIKO26DQaG_K1pfH23_pv743fJeA7rhj_7iFjLUF-3nK0xYhyAGhYy34Dq-DD5g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1753590196</pqid></control><display><type>article</type><title>The clinical impact of platelet-rich plasma on tendinopathy compared to placebo or dry needling injections: A meta-analysis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Tsikopoulos, Konstantinos ; Tsikopoulos, Ioannis ; Simeonidis, Evangelos ; Papathanasiou, Efthymia ; Haidich, Anna-Bettina ; Anastasopoulos, Nikolaos ; Natsis, Konstantinos</creator><creatorcontrib>Tsikopoulos, Konstantinos ; Tsikopoulos, Ioannis ; Simeonidis, Evangelos ; Papathanasiou, Efthymia ; Haidich, Anna-Bettina ; Anastasopoulos, Nikolaos ; Natsis, Konstantinos</creatorcontrib><description>Abstract Objective The purpose of this meta-analysis was to compare the impact of platelet-rich plasma with that of placebo or dry needling injections on tendinopathy. Methods The databases of PubMed, CENTRAL, Scopus, Web of Science, and trial registries, reference lists, and conference abstract books were searched up to December 2014. Adults with tendinopathy in randomized controlled trials were enrolled. The trials compared effect of platelet-rich plasma with that of placebo or dry needling. We used subgroup analysis linked to the anatomical location of the tendinopathy. The primary outcome was pain intensity at two or three and six months after intervention. The secondary outcome was functional disability at three months after treatment. Results Five trials were included. There was a statistically significant difference in favor of the platelet-rich plasma intervention at the second primary outcome time point (SMD −0.48, 95%CIs −0.86 to −0.10, I2 = 0%, p = 0.01) and at the secondary outcome time point (SMD −0.47, 95%CIs −0.85 to −0.09, I2 = 0%, p=0.01). Conclusions Platelet-rich plasma did not provide significantly greater clinical benefit versus placebo or dry needling for the treatment of tendinopathy at a six-month follow-up. However, there was a marginal clinical difference in favor of platelet-rich plasma injections on rotator cuff tendinopathy.</description><identifier>ISSN: 1466-853X</identifier><identifier>EISSN: 1873-1600</identifier><identifier>DOI: 10.1016/j.ptsp.2015.06.003</identifier><identifier>PMID: 26621224</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Blood platelets ; Clinical trials ; Humans ; Injections ; Meta-analysis ; Physical Medicine and Rehabilitation ; Physical therapy ; Plasma ; Platelet-Rich Plasma ; Rehabilitation ; Sports Medicine ; Studies ; Tendinopathy ; Tendinopathy - therapy ; Tendons</subject><ispartof>Physical therapy in sport, 2016-01, Vol.17, p.87-94</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c608t-ae0b05b55dddc085dba3e99d74ca0bfdba315f461703a6f4b3178bfb26a309843</citedby><cites>FETCH-LOGICAL-c608t-ae0b05b55dddc085dba3e99d74ca0bfdba315f461703a6f4b3178bfb26a309843</cites><orcidid>0000-0001-5923-4782</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1753590196?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26621224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsikopoulos, Konstantinos</creatorcontrib><creatorcontrib>Tsikopoulos, Ioannis</creatorcontrib><creatorcontrib>Simeonidis, Evangelos</creatorcontrib><creatorcontrib>Papathanasiou, Efthymia</creatorcontrib><creatorcontrib>Haidich, Anna-Bettina</creatorcontrib><creatorcontrib>Anastasopoulos, Nikolaos</creatorcontrib><creatorcontrib>Natsis, Konstantinos</creatorcontrib><title>The clinical impact of platelet-rich plasma on tendinopathy compared to placebo or dry needling injections: A meta-analysis</title><title>Physical therapy in sport</title><addtitle>Phys Ther Sport</addtitle><description>Abstract Objective The purpose of this meta-analysis was to compare the impact of platelet-rich plasma with that of placebo or dry needling injections on tendinopathy. Methods The databases of PubMed, CENTRAL, Scopus, Web of Science, and trial registries, reference lists, and conference abstract books were searched up to December 2014. Adults with tendinopathy in randomized controlled trials were enrolled. The trials compared effect of platelet-rich plasma with that of placebo or dry needling. We used subgroup analysis linked to the anatomical location of the tendinopathy. The primary outcome was pain intensity at two or three and six months after intervention. The secondary outcome was functional disability at three months after treatment. Results Five trials were included. There was a statistically significant difference in favor of the platelet-rich plasma intervention at the second primary outcome time point (SMD −0.48, 95%CIs −0.86 to −0.10, I2 = 0%, p = 0.01) and at the secondary outcome time point (SMD −0.47, 95%CIs −0.85 to −0.09, I2 = 0%, p=0.01). Conclusions Platelet-rich plasma did not provide significantly greater clinical benefit versus placebo or dry needling for the treatment of tendinopathy at a six-month follow-up. However, there was a marginal clinical difference in favor of platelet-rich plasma injections on rotator cuff tendinopathy.</description><subject>Blood platelets</subject><subject>Clinical trials</subject><subject>Humans</subject><subject>Injections</subject><subject>Meta-analysis</subject><subject>Physical Medicine and Rehabilitation</subject><subject>Physical therapy</subject><subject>Plasma</subject><subject>Platelet-Rich Plasma</subject><subject>Rehabilitation</subject><subject>Sports Medicine</subject><subject>Studies</subject><subject>Tendinopathy</subject><subject>Tendinopathy - therapy</subject><subject>Tendons</subject><issn>1466-853X</issn><issn>1873-1600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl2L1TAQhoso7of-AS8k4I03rZOmSVsRYVnWD1jwwhW8C2ky9eTYJjXJEYp_3pSzq7AX4lUyzDMvzLxvUTyjUFGg4tW-WlJcqhoor0BUAOxBcUq7lpVUADzM_0aIsuPs60lxFuMegOYGe1yc1ELUtK6b0-LXzQ6JnqyzWk3EzovSifiRLJNKOGEqg9W7rYqzIt6RhM5Y5xeVdivRPvMBDUl-QzQOnvhATFiJQzRZ9Ruxbo86We_ia3JBZkyqVE5Na7TxSfFoVFPEp7fvefHl3dXN5Yfy-tP7j5cX16UW0KVSIQzAB86NMRo6bgbFsO9N22gFw7iVlI-NoC0wJcZmYLTthnGohWLQdw07L14edZfgfxwwJjnbqHGalEN_iJK2nDW87_r6f1BKeyEaltEX99C9P4S82lGQ95DBTNVHSgcfY8BRLsHOKqySgtxclHu5uSg3FyUImV3MQ89vpQ_DjObPyJ1tGXhzBDCf7afFIKO26DQaG_K1pfH23_pv743fJeA7rhj_7iFjLUF-3nK0xYhyAGhYy34Dq-DD5g</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Tsikopoulos, Konstantinos</creator><creator>Tsikopoulos, Ioannis</creator><creator>Simeonidis, Evangelos</creator><creator>Papathanasiou, Efthymia</creator><creator>Haidich, Anna-Bettina</creator><creator>Anastasopoulos, Nikolaos</creator><creator>Natsis, Konstantinos</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5923-4782</orcidid></search><sort><creationdate>20160101</creationdate><title>The clinical impact of platelet-rich plasma on tendinopathy compared to placebo or dry needling injections: A meta-analysis</title><author>Tsikopoulos, Konstantinos ; Tsikopoulos, Ioannis ; Simeonidis, Evangelos ; Papathanasiou, Efthymia ; Haidich, Anna-Bettina ; Anastasopoulos, Nikolaos ; Natsis, Konstantinos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c608t-ae0b05b55dddc085dba3e99d74ca0bfdba315f461703a6f4b3178bfb26a309843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Blood platelets</topic><topic>Clinical trials</topic><topic>Humans</topic><topic>Injections</topic><topic>Meta-analysis</topic><topic>Physical Medicine and Rehabilitation</topic><topic>Physical therapy</topic><topic>Plasma</topic><topic>Platelet-Rich Plasma</topic><topic>Rehabilitation</topic><topic>Sports Medicine</topic><topic>Studies</topic><topic>Tendinopathy</topic><topic>Tendinopathy - therapy</topic><topic>Tendons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsikopoulos, Konstantinos</creatorcontrib><creatorcontrib>Tsikopoulos, Ioannis</creatorcontrib><creatorcontrib>Simeonidis, Evangelos</creatorcontrib><creatorcontrib>Papathanasiou, Efthymia</creatorcontrib><creatorcontrib>Haidich, Anna-Bettina</creatorcontrib><creatorcontrib>Anastasopoulos, Nikolaos</creatorcontrib><creatorcontrib>Natsis, Konstantinos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Physical therapy in sport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsikopoulos, Konstantinos</au><au>Tsikopoulos, Ioannis</au><au>Simeonidis, Evangelos</au><au>Papathanasiou, Efthymia</au><au>Haidich, Anna-Bettina</au><au>Anastasopoulos, Nikolaos</au><au>Natsis, Konstantinos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical impact of platelet-rich plasma on tendinopathy compared to placebo or dry needling injections: A meta-analysis</atitle><jtitle>Physical therapy in sport</jtitle><addtitle>Phys Ther Sport</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>17</volume><spage>87</spage><epage>94</epage><pages>87-94</pages><issn>1466-853X</issn><eissn>1873-1600</eissn><abstract>Abstract Objective The purpose of this meta-analysis was to compare the impact of platelet-rich plasma with that of placebo or dry needling injections on tendinopathy. Methods The databases of PubMed, CENTRAL, Scopus, Web of Science, and trial registries, reference lists, and conference abstract books were searched up to December 2014. Adults with tendinopathy in randomized controlled trials were enrolled. The trials compared effect of platelet-rich plasma with that of placebo or dry needling. We used subgroup analysis linked to the anatomical location of the tendinopathy. The primary outcome was pain intensity at two or three and six months after intervention. The secondary outcome was functional disability at three months after treatment. Results Five trials were included. There was a statistically significant difference in favor of the platelet-rich plasma intervention at the second primary outcome time point (SMD −0.48, 95%CIs −0.86 to −0.10, I2 = 0%, p = 0.01) and at the secondary outcome time point (SMD −0.47, 95%CIs −0.85 to −0.09, I2 = 0%, p=0.01). Conclusions Platelet-rich plasma did not provide significantly greater clinical benefit versus placebo or dry needling for the treatment of tendinopathy at a six-month follow-up. However, there was a marginal clinical difference in favor of platelet-rich plasma injections on rotator cuff tendinopathy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26621224</pmid><doi>10.1016/j.ptsp.2015.06.003</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5923-4782</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1466-853X |
| ispartof | Physical therapy in sport, 2016-01, Vol.17, p.87-94 |
| issn | 1466-853X 1873-1600 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1753459892 |
| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Blood platelets Clinical trials Humans Injections Meta-analysis Physical Medicine and Rehabilitation Physical therapy Plasma Platelet-Rich Plasma Rehabilitation Sports Medicine Studies Tendinopathy Tendinopathy - therapy Tendons |
| title | The clinical impact of platelet-rich plasma on tendinopathy compared to placebo or dry needling injections: A meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T08%3A28%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20clinical%20impact%20of%20platelet-rich%20plasma%20on%20tendinopathy%20compared%20to%20placebo%20or%20dry%20needling%20injections:%20A%20meta-analysis&rft.jtitle=Physical%20therapy%20in%20sport&rft.au=Tsikopoulos,%20Konstantinos&rft.date=2016-01-01&rft.volume=17&rft.spage=87&rft.epage=94&rft.pages=87-94&rft.issn=1466-853X&rft.eissn=1873-1600&rft_id=info:doi/10.1016/j.ptsp.2015.06.003&rft_dat=%3Cproquest_cross%3E1751196643%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1753590196&rft_id=info:pmid/26621224&rft_els_id=1_s2_0_S1466853X15000437&rfr_iscdi=true |