Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis

ObjectiveHepatic stellate cells (HSCs) contain a number of bioactive metabolites or their precursors including retinoids in their characteristic lipid droplets. The loss of lipid droplets and retinoids is a hallmark of HSC activation, but it remains unclear whether this loss promotes HSC activation,...

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Veröffentlicht in:	Gut 2011-09, Vol.60 (9), p.1260-1268
Hauptverfasser:	Kluwe, Johannes, Wongsiriroj, Nuttaporn, Troeger, Juliane S, Gwak, Geum-Youn, Dapito, Dianne H, Pradere, Jean-Philippe, Jiang, Hongfeng, Siddiqi, Maham, Piantedosi, Roseann, O'Byrne, Sheila M, Blaner, William S, Schwabe, Robert F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Acyltransferases - deficiency Acyltransferases - metabolism Animals bile duct ligation Biological and medical sciences Carbon Tetrachloride carbontetrachloride Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cells, Cultured Diethylnitrosamine Down-Regulation fibrogenesis Gastroenterology. Liver. Pancreas. Abdomen Gene expression hepatic stellate cell Hepatic Stellate Cells - metabolism hepatocellular carcinoma Kinases Lipids Liver cancer Liver cirrhosis Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver fibrosis Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology Liver Neoplasms, Experimental - prevention & control Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mice Mice, Inbred C57BL Other diseases. Semiology Rodents Studies Tumorigenesis Tumors Wound healing
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