A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

Objective Several epidemiological studies have shown that regular exercise can prevent the onset of colon cancer, although the underlying mechanism is unclear. Myokines are secreted skeletal muscle proteins responsible for some exercise-induced health benefits including metabolic improvement and ant...

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Veröffentlicht in:	Gut 2013-06, Vol.62 (6), p.882-889
Hauptverfasser:	Aoi, Wataru, Naito, Yuji, Takagi, Tomohisa, Tanimura, Yuko, Takanami, Yoshikazu, Kawai, Yukari, Sakuma, Kunihiro, Hang, Liu Po, Mizushima, Katsura, Hirai, Yasuko, Koyama, Ryota, Wada, Sayori, Higashi, Akane, Kokura, Satoshi, Ichikawa, Hiroshi, Yoshikawa, Toshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberrant Crypt Foci - metabolism Aberrant Crypt Foci - physiopathology Aberrant Crypt Foci - prevention & control ageing amino acids Animals antioxidants Apoptosis Apoptosis - physiology Cardiovascular disease cell biology Cell Transformation, Neoplastic - metabolism colon cancer Colonic Neoplasms - metabolism Colonic Neoplasms - physiopathology Colonic Neoplasms - prevention & control Colorectal cancer colorectal physiology Diabetes Epidemiology Exercise Exercise - physiology Experiments gastric inflammation Glycoproteins - metabolism Humans ibd ibd models immunology inflammatory bowel disease inflammatory mediators Male Metabolism Mice Mice, Inbred ICR Mice, Knockout mucosal repair Muscle Fibers, Skeletal - metabolism Musculoskeletal system Oligonucleotide Array Sequence Analysis Osteonectin Oxidative stress Physical Conditioning, Animal - physiology Physical fitness Prevention Proteins Review boards Rodents Skeletal muscle Studies Tumor Cells, Cultured Tumor Suppressor Proteins - metabolism Tumorigenesis Variance analysis
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