Fertility and sexual function in long‐term survivors of haematological malignancy: using patient‐reported outcome measures to assess a neglected area of need in the late effects clinic
Summary Problems of sexual function and fertility in long‐term survivors (≥5 years) of haematological malignancy are often neglected in clinic. Our centre carried out a questionnaire study in this population addressing patient‐perceived fertility and sexual function. 718 patients responded (56% of t...
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| Veröffentlicht in: | British journal of haematology 2014-02, Vol.164 (4), p.526-535 |
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| container_title | British journal of haematology |
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| creator | Greaves, Paul Sarker, Shah‐Jalal Chowdhury, Kashfia Johnson, Rachel Matthews, Janet Matthews, Rebecca Smith, Matthew Korszun, Ania Gribben, John G. Lister, T. Andrew |
| description | Summary
Problems of sexual function and fertility in long‐term survivors (≥5 years) of haematological malignancy are often neglected in clinic. Our centre carried out a questionnaire study in this population addressing patient‐perceived fertility and sexual function. 718 patients responded (56% of those invited; 39% Hodgkin, 45% non‐Hodgkin lymphoma, 16% acute leukaemia). Respondent women were more likely to remain childless than a normal control population. Self‐reported infertility was more likely in men than women [odds ratio (OR) 1·77, P = 0·001]. Myeloablative therapy increased the likelihood of childlessness (OR 2·48, P = 0·004). Few attended fertility support services (12%). 24% of men banked sperm and 29% of these used the sample, of which 46% resulted in successful pregnancy. Fertility clinic attendance and sperm storage was more likely post‐1990 (OR 4·05, P |
| doi_str_mv | 10.1111/bjh.12651 |
| format | Article |
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Problems of sexual function and fertility in long‐term survivors (≥5 years) of haematological malignancy are often neglected in clinic. Our centre carried out a questionnaire study in this population addressing patient‐perceived fertility and sexual function. 718 patients responded (56% of those invited; 39% Hodgkin, 45% non‐Hodgkin lymphoma, 16% acute leukaemia). Respondent women were more likely to remain childless than a normal control population. Self‐reported infertility was more likely in men than women [odds ratio (OR) 1·77, P = 0·001]. Myeloablative therapy increased the likelihood of childlessness (OR 2·48, P = 0·004). Few attended fertility support services (12%). 24% of men banked sperm and 29% of these used the sample, of which 46% resulted in successful pregnancy. Fertility clinic attendance and sperm storage was more likely post‐1990 (OR 4·05, P < 0·001; OR 5·05, P < 0·001 respectively). Reporting a negative impact of cancer on sexual function was more common in women than men (OR 2·20, P < 0·001), and increased with current age and age at diagnosis (by 3–4% per year, P ≤ 0·001) but decreased with longer follow‐up (by 2%/year, P = 0·005). Patients on anti‐depressants and those reporting cancer‐related body change/appearance concerns more frequently reported a negative impact (P < 0·04 and P < 0·03 respectively). These self‐reported outcomes confirm literature findings, suggest improvement over time, but highlight a need for involvement of support services.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/bjh.12651</identifier><identifier>PMID: 24236665</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Female ; fertility ; haematological malignancy ; Hematologic and hematopoietic diseases ; Hematologic Neoplasms - physiopathology ; Humans ; Infertility - etiology ; Infertility - physiopathology ; long‐term survivors ; Male ; Medical sciences ; Pregnancy ; Quality of Life ; Self Report ; Sexual Dysfunction, Physiological - etiology ; Sexual Dysfunction, Physiological - physiopathology ; sexual function ; Surveys and Questionnaires ; Survivors ; Treatment Outcome ; Tumors ; Young Adult</subject><ispartof>British journal of haematology, 2014-02, Vol.164 (4), p.526-535</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2013 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4231-c0332d76dd1fd3b086cd43dec7a6c939f677391f706fb066dd9961de41512d6b3</citedby><cites>FETCH-LOGICAL-c4231-c0332d76dd1fd3b086cd43dec7a6c939f677391f706fb066dd9961de41512d6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjh.12651$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjh.12651$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28318624$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24236665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greaves, Paul</creatorcontrib><creatorcontrib>Sarker, Shah‐Jalal</creatorcontrib><creatorcontrib>Chowdhury, Kashfia</creatorcontrib><creatorcontrib>Johnson, Rachel</creatorcontrib><creatorcontrib>Matthews, Janet</creatorcontrib><creatorcontrib>Matthews, Rebecca</creatorcontrib><creatorcontrib>Smith, Matthew</creatorcontrib><creatorcontrib>Korszun, Ania</creatorcontrib><creatorcontrib>Gribben, John G.</creatorcontrib><creatorcontrib>Lister, T. Andrew</creatorcontrib><title>Fertility and sexual function in long‐term survivors of haematological malignancy: using patient‐reported outcome measures to assess a neglected area of need in the late effects clinic</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Problems of sexual function and fertility in long‐term survivors (≥5 years) of haematological malignancy are often neglected in clinic. Our centre carried out a questionnaire study in this population addressing patient‐perceived fertility and sexual function. 718 patients responded (56% of those invited; 39% Hodgkin, 45% non‐Hodgkin lymphoma, 16% acute leukaemia). Respondent women were more likely to remain childless than a normal control population. Self‐reported infertility was more likely in men than women [odds ratio (OR) 1·77, P = 0·001]. Myeloablative therapy increased the likelihood of childlessness (OR 2·48, P = 0·004). Few attended fertility support services (12%). 24% of men banked sperm and 29% of these used the sample, of which 46% resulted in successful pregnancy. Fertility clinic attendance and sperm storage was more likely post‐1990 (OR 4·05, P < 0·001; OR 5·05, P < 0·001 respectively). Reporting a negative impact of cancer on sexual function was more common in women than men (OR 2·20, P < 0·001), and increased with current age and age at diagnosis (by 3–4% per year, P ≤ 0·001) but decreased with longer follow‐up (by 2%/year, P = 0·005). Patients on anti‐depressants and those reporting cancer‐related body change/appearance concerns more frequently reported a negative impact (P < 0·04 and P < 0·03 respectively). These self‐reported outcomes confirm literature findings, suggest improvement over time, but highlight a need for involvement of support services.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>fertility</subject><subject>haematological malignancy</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematologic Neoplasms - physiopathology</subject><subject>Humans</subject><subject>Infertility - etiology</subject><subject>Infertility - physiopathology</subject><subject>long‐term survivors</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Quality of Life</subject><subject>Self Report</subject><subject>Sexual Dysfunction, Physiological - etiology</subject><subject>Sexual Dysfunction, Physiological - physiopathology</subject><subject>sexual function</subject><subject>Surveys and Questionnaires</subject><subject>Survivors</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1u1DAUB3ALgehQWHAB5A0SLNLaceIk7KCiFFSJDawjx36eceXYg59TmB1H4ECchpPgYQZYIbyxLP3eh_Un5DFnZ7yc8-lmc8Zr2fI7ZMWFbKuaN_wuWTHGuoqzpj8hDxBvGOOCtfw-OambWkgp2xX5fgkpO-_yjqpgKMKXRXlql6Czi4G6QH0M6x9fv2VIM8Ul3brbmJBGSzcKZpWjj2unS82svFsHFfTuBV3QhTXdquwg5FKcYBtTBkPjknWcgc6gSi9AmiNViIBIFQ2w9qD3TCVQ-xEByqPskDdAvcpAwdoikGrvgtMPyT2rPMKj431KPl6-_nBxVV2_f_P24uV1pcs_eaWZELXppDHcGjGxXmrTCAO6U1IPYrCy68TAbceknZgsbhgkN9DwltdGTuKUPDv03ab4aQHM4-xQg_cqQFxw5F0rmrZnTfd_2gx1x9t-kIU-P1CdImICO26Tm1XajZyN-1zHkuv4K9dinxzbLtMM5o_8HWQBT49AYUnDphKEw7-uF7yXdVPc-cF9dh52_544vnp3dRj9E6j7vxQ</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Greaves, Paul</creator><creator>Sarker, Shah‐Jalal</creator><creator>Chowdhury, Kashfia</creator><creator>Johnson, Rachel</creator><creator>Matthews, Janet</creator><creator>Matthews, Rebecca</creator><creator>Smith, Matthew</creator><creator>Korszun, Ania</creator><creator>Gribben, John G.</creator><creator>Lister, T. Andrew</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201402</creationdate><title>Fertility and sexual function in long‐term survivors of haematological malignancy: using patient‐reported outcome measures to assess a neglected area of need in the late effects clinic</title><author>Greaves, Paul ; Sarker, Shah‐Jalal ; Chowdhury, Kashfia ; Johnson, Rachel ; Matthews, Janet ; Matthews, Rebecca ; Smith, Matthew ; Korszun, Ania ; Gribben, John G. ; Lister, T. Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4231-c0332d76dd1fd3b086cd43dec7a6c939f677391f706fb066dd9961de41512d6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>fertility</topic><topic>haematological malignancy</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematologic Neoplasms - physiopathology</topic><topic>Humans</topic><topic>Infertility - etiology</topic><topic>Infertility - physiopathology</topic><topic>long‐term survivors</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Quality of Life</topic><topic>Self Report</topic><topic>Sexual Dysfunction, Physiological - etiology</topic><topic>Sexual Dysfunction, Physiological - physiopathology</topic><topic>sexual function</topic><topic>Surveys and Questionnaires</topic><topic>Survivors</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greaves, Paul</creatorcontrib><creatorcontrib>Sarker, Shah‐Jalal</creatorcontrib><creatorcontrib>Chowdhury, Kashfia</creatorcontrib><creatorcontrib>Johnson, Rachel</creatorcontrib><creatorcontrib>Matthews, Janet</creatorcontrib><creatorcontrib>Matthews, Rebecca</creatorcontrib><creatorcontrib>Smith, Matthew</creatorcontrib><creatorcontrib>Korszun, Ania</creatorcontrib><creatorcontrib>Gribben, John G.</creatorcontrib><creatorcontrib>Lister, T. Andrew</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greaves, Paul</au><au>Sarker, Shah‐Jalal</au><au>Chowdhury, Kashfia</au><au>Johnson, Rachel</au><au>Matthews, Janet</au><au>Matthews, Rebecca</au><au>Smith, Matthew</au><au>Korszun, Ania</au><au>Gribben, John G.</au><au>Lister, T. Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fertility and sexual function in long‐term survivors of haematological malignancy: using patient‐reported outcome measures to assess a neglected area of need in the late effects clinic</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2014-02</date><risdate>2014</risdate><volume>164</volume><issue>4</issue><spage>526</spage><epage>535</epage><pages>526-535</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
Problems of sexual function and fertility in long‐term survivors (≥5 years) of haematological malignancy are often neglected in clinic. Our centre carried out a questionnaire study in this population addressing patient‐perceived fertility and sexual function. 718 patients responded (56% of those invited; 39% Hodgkin, 45% non‐Hodgkin lymphoma, 16% acute leukaemia). Respondent women were more likely to remain childless than a normal control population. Self‐reported infertility was more likely in men than women [odds ratio (OR) 1·77, P = 0·001]. Myeloablative therapy increased the likelihood of childlessness (OR 2·48, P = 0·004). Few attended fertility support services (12%). 24% of men banked sperm and 29% of these used the sample, of which 46% resulted in successful pregnancy. Fertility clinic attendance and sperm storage was more likely post‐1990 (OR 4·05, P < 0·001; OR 5·05, P < 0·001 respectively). Reporting a negative impact of cancer on sexual function was more common in women than men (OR 2·20, P < 0·001), and increased with current age and age at diagnosis (by 3–4% per year, P ≤ 0·001) but decreased with longer follow‐up (by 2%/year, P = 0·005). Patients on anti‐depressants and those reporting cancer‐related body change/appearance concerns more frequently reported a negative impact (P < 0·04 and P < 0·03 respectively). These self‐reported outcomes confirm literature findings, suggest improvement over time, but highlight a need for involvement of support services.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>24236665</pmid><doi>10.1111/bjh.12651</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Female fertility haematological malignancy Hematologic and hematopoietic diseases Hematologic Neoplasms - physiopathology Humans Infertility - etiology Infertility - physiopathology long‐term survivors Male Medical sciences Pregnancy Quality of Life Self Report Sexual Dysfunction, Physiological - etiology Sexual Dysfunction, Physiological - physiopathology sexual function Surveys and Questionnaires Survivors Treatment Outcome Tumors Young Adult |
| title | Fertility and sexual function in long‐term survivors of haematological malignancy: using patient‐reported outcome measures to assess a neglected area of need in the late effects clinic |
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