Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells
Oleanolic acid (OA) and its several derivatives possess chemopreventive and chemotherapeutic functions against a series of cancer types. Many chemotherapeutic compounds are effective in improving the quality of life and prolonging the survival of patients with gastric cancer, therefore progress in t...
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| Veröffentlicht in: | Oncology reports 2016-02, Vol.35 (2), p.1101-1108 |
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| creator | GAO, LEI XU, ZHEN WANG, YAN SUN, BIN SONG, ZHICHENG YANG, BINING LIU, XU LIN, YUAN PENG, JINYONG HAN, GUOZHU WANG, SHISHENG TANG, ZEYAO |
| description | Oleanolic acid (OA) and its several derivatives possess chemopreventive and chemotherapeutic functions against a series of cancer types. Many chemotherapeutic compounds are effective in improving the quality of life and prolonging the survival of patients with gastric cancer, therefore progress in the treatment of gastric cancer, especially the anticancer effects of OA derivatives must be achieved. The inhibitory effect of SZC017, a newly synthesized derivative of OA, on cell viability was determined by MTT assay. Furthermore, flow cytometry, transmission electron microscopy, and western blot analysis revealed that the inhibition of cell viability by OA was mediated by triggering the intrinsic apoptosis of gastric cancer cells, and inducing S phase arrest of SGC7901 cells. Mechanistically, SZC017 was effective against gastric cancer cells via inhibiting Akt/NF-κB signaling and topoisomerase I and IIα proteins. Taken together, our data indicate that SZC017 may be a potential chemotherapeutic agent against gastric cancer cells. |
| doi_str_mv | 10.3892/or.2015.4447 |
| format | Article |
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Many chemotherapeutic compounds are effective in improving the quality of life and prolonging the survival of patients with gastric cancer, therefore progress in the treatment of gastric cancer, especially the anticancer effects of OA derivatives must be achieved. The inhibitory effect of SZC017, a newly synthesized derivative of OA, on cell viability was determined by MTT assay. Furthermore, flow cytometry, transmission electron microscopy, and western blot analysis revealed that the inhibition of cell viability by OA was mediated by triggering the intrinsic apoptosis of gastric cancer cells, and inducing S phase arrest of SGC7901 cells. Mechanistically, SZC017 was effective against gastric cancer cells via inhibiting Akt/NF-κB signaling and topoisomerase I and IIα proteins. Taken together, our data indicate that SZC017 may be a potential chemotherapeutic agent against gastric cancer cells.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>DOI: 10.3892/or.2015.4447</identifier><identifier>PMID: 26718492</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Care and treatment ; Cell cycle ; Cell Cycle - drug effects ; Cell Line, Tumor ; Cellular signal transduction ; Chromatography ; Cytoplasm ; Deoxyribonucleic acid ; DNA ; DNA Topoisomerases, Type I - biosynthesis ; DNA Topoisomerases, Type I - genetics ; Drug Screening Assays, Antitumor ; Gastric cancer ; Gene expression ; Health aspects ; Humans ; I-kappa B Proteins - biosynthesis ; I-kappa B Proteins - genetics ; MGC-803 ; Neoplasm Proteins - antagonists & inhibitors ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - genetics ; NF-kappa B - antagonists & inhibitors ; NF-KappaB Inhibitor alpha ; Oleanolic Acid - analogs & derivatives ; Oleanolic Acid - chemical synthesis ; Oleanolic Acid - pharmacology ; oleanolic acid derivative ; Penicillin ; Phosphorylation ; Piperidines - chemical synthesis ; Piperidines - pharmacology ; Proto-Oncogene Proteins c-akt - biosynthesis ; Proto-Oncogene Proteins c-akt - genetics ; SGC-7901 ; Signal Transduction - drug effects ; Stomach cancer ; Stomach Neoplasms - pathology ; SZC017 ; Terpenes ; Topoisomerase Inhibitors - chemical synthesis ; Topoisomerase Inhibitors - pharmacology</subject><ispartof>Oncology reports, 2016-02, Vol.35 (2), p.1101-1108</ispartof><rights>Copyright: © Gao et al.</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-d207ed94db94b8035e69b882c0d685ad1963bc5a151c74692107427750b1fc9a3</citedby><cites>FETCH-LOGICAL-c552t-d207ed94db94b8035e69b882c0d685ad1963bc5a151c74692107427750b1fc9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26718492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GAO, LEI</creatorcontrib><creatorcontrib>XU, ZHEN</creatorcontrib><creatorcontrib>WANG, YAN</creatorcontrib><creatorcontrib>SUN, BIN</creatorcontrib><creatorcontrib>SONG, ZHICHENG</creatorcontrib><creatorcontrib>YANG, BINING</creatorcontrib><creatorcontrib>LIU, XU</creatorcontrib><creatorcontrib>LIN, YUAN</creatorcontrib><creatorcontrib>PENG, JINYONG</creatorcontrib><creatorcontrib>HAN, GUOZHU</creatorcontrib><creatorcontrib>WANG, SHISHENG</creatorcontrib><creatorcontrib>TANG, ZEYAO</creatorcontrib><title>Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>Oleanolic acid (OA) and its several derivatives possess chemopreventive and chemotherapeutic functions against a series of cancer types. Many chemotherapeutic compounds are effective in improving the quality of life and prolonging the survival of patients with gastric cancer, therefore progress in the treatment of gastric cancer, especially the anticancer effects of OA derivatives must be achieved. The inhibitory effect of SZC017, a newly synthesized derivative of OA, on cell viability was determined by MTT assay. Furthermore, flow cytometry, transmission electron microscopy, and western blot analysis revealed that the inhibition of cell viability by OA was mediated by triggering the intrinsic apoptosis of gastric cancer cells, and inducing S phase arrest of SGC7901 cells. Mechanistically, SZC017 was effective against gastric cancer cells via inhibiting Akt/NF-κB signaling and topoisomerase I and IIα proteins. Taken together, our data indicate that SZC017 may be a potential chemotherapeutic agent against gastric cancer cells.</description><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Care and treatment</subject><subject>Cell cycle</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cellular signal transduction</subject><subject>Chromatography</subject><subject>Cytoplasm</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Topoisomerases, Type I - biosynthesis</subject><subject>DNA Topoisomerases, Type I - genetics</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Humans</subject><subject>I-kappa B Proteins - biosynthesis</subject><subject>I-kappa B Proteins - genetics</subject><subject>MGC-803</subject><subject>Neoplasm Proteins - antagonists & inhibitors</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>NF-kappa B - antagonists & inhibitors</subject><subject>NF-KappaB Inhibitor alpha</subject><subject>Oleanolic Acid - analogs & derivatives</subject><subject>Oleanolic Acid - chemical synthesis</subject><subject>Oleanolic Acid - pharmacology</subject><subject>oleanolic acid derivative</subject><subject>Penicillin</subject><subject>Phosphorylation</subject><subject>Piperidines - chemical synthesis</subject><subject>Piperidines - pharmacology</subject><subject>Proto-Oncogene Proteins c-akt - biosynthesis</subject><subject>Proto-Oncogene Proteins c-akt - genetics</subject><subject>SGC-7901</subject><subject>Signal Transduction - drug effects</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - pathology</subject><subject>SZC017</subject><subject>Terpenes</subject><subject>Topoisomerase Inhibitors - chemical synthesis</subject><subject>Topoisomerase Inhibitors - pharmacology</subject><issn>1021-335X</issn><issn>1791-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkc9rFDEUxwex2Fq9eZaAIB521rz8nByXRa1Q6EEF8RIzSaabMpOsycyC_31n6NpakRwSvvm873uPb1W9ArymjSLvU14TDHzNGJNPqjOQCmrCKDyd35hATSn_flo9L-UGYyKxUM-qUyIkNEyRs-rnJo7Bmmh9Rr7rvB1R6tCXH1sMcoUMiunge-R8DgczhoNfflPvTUx9sMjY4FYoRbSbBhPRtSljnuWjn_V9X15UJ53pi395vM-rbx8_fN1e1JdXnz5vN5e15ZyMtSNYeqeYaxVrG0y5F6ptGmKxEw03DpSgreUGOFjJhCKAJSNSctxCZ5Wh59W7O999Tr8mX0Y9hLJMYKJPU9EgOWWMCCZn9M0_6E2acpyn06AoEY0gXD1Q16b3OsQujdnYxVRvGOOcMybITK3_Q83H-SHYFH0XZv1Rwdu_Cnbe9OOupH4aQ4rlMbi6A21OpWTf6X0Og8m_NWC9JK9T1kvyekl-xl8fl5rawbt7-E_UD43L3kQXXCr3TMo15TUmNQAGegtDRLBe</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>GAO, LEI</creator><creator>XU, ZHEN</creator><creator>WANG, YAN</creator><creator>SUN, BIN</creator><creator>SONG, ZHICHENG</creator><creator>YANG, BINING</creator><creator>LIU, XU</creator><creator>LIN, YUAN</creator><creator>PENG, JINYONG</creator><creator>HAN, GUOZHU</creator><creator>WANG, SHISHENG</creator><creator>TANG, ZEYAO</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells</title><author>GAO, LEI ; XU, ZHEN ; WANG, YAN ; SUN, BIN ; SONG, ZHICHENG ; YANG, BINING ; LIU, XU ; LIN, YUAN ; PENG, JINYONG ; HAN, GUOZHU ; WANG, SHISHENG ; TANG, ZEYAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-d207ed94db94b8035e69b882c0d685ad1963bc5a151c74692107427750b1fc9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Care and treatment</topic><topic>Cell cycle</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cellular signal transduction</topic><topic>Chromatography</topic><topic>Cytoplasm</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Topoisomerases, Type I - biosynthesis</topic><topic>DNA Topoisomerases, Type I - genetics</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Health aspects</topic><topic>Humans</topic><topic>I-kappa B Proteins - biosynthesis</topic><topic>I-kappa B Proteins - genetics</topic><topic>MGC-803</topic><topic>Neoplasm Proteins - antagonists & inhibitors</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - genetics</topic><topic>NF-kappa B - antagonists & inhibitors</topic><topic>NF-KappaB Inhibitor alpha</topic><topic>Oleanolic Acid - analogs & derivatives</topic><topic>Oleanolic Acid - chemical synthesis</topic><topic>Oleanolic Acid - pharmacology</topic><topic>oleanolic acid derivative</topic><topic>Penicillin</topic><topic>Phosphorylation</topic><topic>Piperidines - chemical synthesis</topic><topic>Piperidines - pharmacology</topic><topic>Proto-Oncogene Proteins c-akt - biosynthesis</topic><topic>Proto-Oncogene Proteins c-akt - genetics</topic><topic>SGC-7901</topic><topic>Signal Transduction - drug effects</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - pathology</topic><topic>SZC017</topic><topic>Terpenes</topic><topic>Topoisomerase Inhibitors - chemical synthesis</topic><topic>Topoisomerase Inhibitors - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GAO, LEI</creatorcontrib><creatorcontrib>XU, ZHEN</creatorcontrib><creatorcontrib>WANG, YAN</creatorcontrib><creatorcontrib>SUN, BIN</creatorcontrib><creatorcontrib>SONG, ZHICHENG</creatorcontrib><creatorcontrib>YANG, BINING</creatorcontrib><creatorcontrib>LIU, XU</creatorcontrib><creatorcontrib>LIN, YUAN</creatorcontrib><creatorcontrib>PENG, JINYONG</creatorcontrib><creatorcontrib>HAN, GUOZHU</creatorcontrib><creatorcontrib>WANG, SHISHENG</creatorcontrib><creatorcontrib>TANG, ZEYAO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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Many chemotherapeutic compounds are effective in improving the quality of life and prolonging the survival of patients with gastric cancer, therefore progress in the treatment of gastric cancer, especially the anticancer effects of OA derivatives must be achieved. The inhibitory effect of SZC017, a newly synthesized derivative of OA, on cell viability was determined by MTT assay. Furthermore, flow cytometry, transmission electron microscopy, and western blot analysis revealed that the inhibition of cell viability by OA was mediated by triggering the intrinsic apoptosis of gastric cancer cells, and inducing S phase arrest of SGC7901 cells. Mechanistically, SZC017 was effective against gastric cancer cells via inhibiting Akt/NF-κB signaling and topoisomerase I and IIα proteins. Taken together, our data indicate that SZC017 may be a potential chemotherapeutic agent against gastric cancer cells.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>26718492</pmid><doi>10.3892/or.2015.4447</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Care and treatment Cell cycle Cell Cycle - drug effects Cell Line, Tumor Cellular signal transduction Chromatography Cytoplasm Deoxyribonucleic acid DNA DNA Topoisomerases, Type I - biosynthesis DNA Topoisomerases, Type I - genetics Drug Screening Assays, Antitumor Gastric cancer Gene expression Health aspects Humans I-kappa B Proteins - biosynthesis I-kappa B Proteins - genetics MGC-803 Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics NF-kappa B - antagonists & inhibitors NF-KappaB Inhibitor alpha Oleanolic Acid - analogs & derivatives Oleanolic Acid - chemical synthesis Oleanolic Acid - pharmacology oleanolic acid derivative Penicillin Phosphorylation Piperidines - chemical synthesis Piperidines - pharmacology Proto-Oncogene Proteins c-akt - biosynthesis Proto-Oncogene Proteins c-akt - genetics SGC-7901 Signal Transduction - drug effects Stomach cancer Stomach Neoplasms - pathology SZC017 Terpenes Topoisomerase Inhibitors - chemical synthesis Topoisomerase Inhibitors - pharmacology |
| title | Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells |
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