TMC-95A, B, C, and D, Novel Proteasome Inhibitors Produced by Apiospora montagnei Sacc. TC 1093: Taxonomy, Production, Isolation, and Biological Activities

In our course of screening for novel proteasome inhibitors, TMC-95A and its diastereomers, TMC-95B to D, were isolated from the fermentation broth of Apiospora montagnei Sacc. TC 1093. TMC-95A inhibited the chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH...

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Veröffentlicht in:	Journal of antibiotics 2000/02/25, Vol.53(2), pp.105-109
Hauptverfasser:	KOGUCHI, YUTAKA, KOHNO, JUN, NISHIO, MAKI, TAKAHASHI, KOHEI, OKUDA, TORU, OHNUKI, TETSUO, KOMATSUBARA, SABURO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic agents Apiospora montagnei Applied microbiology Biological and medical sciences Chemotherapic agents Chymotrypsin - metabolism Colonic Neoplasms - drug therapy Cysteine Endopeptidases - drug effects eptidylglutamylpeptide Fermentation Fundamental and applied biological sciences. Psychology General aspects HL-60 Cells - drug effects Humans Hydrolysis Inhibitory Concentration 50 Medical sciences Microbiology Mitosporic Fungi - classification Mitosporic Fungi - metabolism Multienzyme Complexes - drug effects Peptides - metabolism Peptides, Cyclic - isolation & purification Peptides, Cyclic - metabolism Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Protease Inhibitors - isolation & purification Protease Inhibitors - metabolism Protease Inhibitors - pharmacology Proteasome Endopeptidase Complex proteasome inhibitors TMC-95A TMC-95B TMC-95C TMC-95D Trypsin - metabolism Tumor Cells, Cultured
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