Lack of oestrogenic effects of food preservatives (parabens) in uterotrophic assays

The oestrogenic activity of the parabens, methyl-, ethyl- and propyl p-hydroxybenzoate, widely used as antimicrobials in food, and butyl p-hydroxybenzoate, which is used in cosmetic products, and their shared main metabolite p-hydroxybenzoic acid was investigated in a mouse uterotrophic assay. Immat...

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Veröffentlicht in:	Food and chemical toxicology 2000-04, Vol.38 (4), p.319-323
Hauptverfasser:	Hossaini, A., Larsen, J.-J., Larsen, J.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-hydroxybenzoic acid Administration, Oral Analysis of Variance Animals bioassays Biological and medical sciences Body Weight - drug effects butyl p-hydroxybenzoate estrogenic properties ethyl p-hydroxybenzoate ethylparaben Female food preservatives Food Preservatives - administration & dosage Food Preservatives - metabolism Food Preservatives - toxicity Food toxicology Injections, Subcutaneous Medical sciences methylparaben Mice mouse oestrogen oral administration Organ Size - drug effects p-Hydroxybenzoic acid parabens Parabens - administration & dosage Parabens - metabolism Parabens - toxicity propyl p-hydroxybenzoate rat Rats Rats, Wistar Species Specificity Structure-Activity Relationship toxicity Toxicology uterotrophic assay uterus Uterus - drug effects weight
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