Aging induced loss of stemness with concomitant gain of myogenic properties of a pure population of CD34+/CD45− muscle derived stem cells

Aging is accompanied by the functional decline of cells, tissues, and organs, as well as, a striking increase in susceptibility to a wide range of diseases. Within a tissue, both differentiated cells and adult stem cells are susceptible to intrinsic and extrinsic changes while aging. Muscle derived...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The international journal of biochemistry & cell biology 2016-01, Vol.70, p.1-12
Hauptverfasser:	Bose, Bipasha, P, Sudheer Shenoy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - cytology Adult Stem Cells - metabolism Adult Stem Cells - transplantation Aging Aging - genetics Aging - metabolism Aging - pathology Animals Antigens, CD34 - genetics Antigens, CD34 - metabolism Biomarkers - metabolism Cell Differentiation Cellular Senescence Disease Models, Animal Dystrophin - genetics Dystrophin - metabolism Flow Cytometry Gene Expression Leukocyte Common Antigens - deficiency Leukocyte Common Antigens - genetics Male Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice Mice, Inbred C57BL Mice, Inbred mdx Muscle derived stem cells Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism Muscular Dystrophies - genetics Muscular Dystrophies - metabolism Muscular Dystrophies - pathology Myoblasts Myoblasts - cytology Myoblasts - metabolism MyoD Protein - genetics MyoD Protein - metabolism Myogenesis Skeletal muscle
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!