A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferi

Summary Borrelia burgdorferi, the aetiologic agent of Lyme disease, modulates gene expression in response to changes imposed by its arthropod vector and mammalian hosts. As reactive oxygen species (ROS) are known to vary in these environments, we asked how B. burgdorferi responds to oxidative stress...

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Veröffentlicht in:	Molecular microbiology 2004-12, Vol.54 (5), p.1352-1363
Hauptverfasser:	Seshu, J., Boylan, Julie A., Hyde, Jenny A., Swingle, Kristen L., Gherardini, Frank C., Skare, Jonathan T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - metabolism Adaptation, Physiological Adhesins, Bacterial - genetics Adhesins, Bacterial - metabolism Amino Acid Substitution Artificial Gene Fusion Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins - physiology Bacteriology beta-Galactosidase - genetics beta-Galactosidase - metabolism Biological and medical sciences Borrelia burgdorferi Borrelia burgdorferi - genetics Borrelia burgdorferi - physiology Escherichia coli Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Genes, Regulator Genes, Reporter Microbiology Miscellaneous Mutation Oxidative Stress Promoter Regions, Genetic Protein Binding Repressor Proteins - genetics Repressor Proteins - physiology Superoxide Dismutase - genetics Superoxide Dismutase - metabolism tert-Butylhydroperoxide - toxicity Transcription Factors - genetics Transcription Factors - physiology
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