Cytomegalovirus retinitis in advanced HIV-infected patients treated with protease inhibitors : Incidence and outcome over 2 years
We prospectively studied the incidence of cytomegalovirus (CMV) retinitis in 93 patients treated with highly active antiretroviral therapy (HAART) containing a protease inhibitor (PI), during a median follow-up period of 24 months. The median initial CD4 super(+) count was 22 cells/ mu l (range, 1-3...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 1999-11, Vol.22 (3), p.228-234 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | LABETOULLE, M GOUJARD, C FRAU, E ROGIER, H NIESSEN, F FURLAN, V LANTZ, O LECOINTE, D DELFRAISSY, J.-F OFFRET, H |
| description | We prospectively studied the incidence of cytomegalovirus (CMV) retinitis in 93 patients treated with highly active antiretroviral therapy (HAART) containing a protease inhibitor (PI), during a median follow-up period of 24 months. The median initial CD4 super(+) count was 22 cells/ mu l (range, 1-311 cells/ mu l), and the median plasma HIV viral load was 5.1 log sub(10) copies/ml (range, 2.4-6.4 log sub(10) copies/ml). The fundus was examined monthly in patients with a history of CMV retinitis or an initial CD4 super(+) count |
| doi_str_mv | 10.1097/00126334-199911010-00003 |
| format | Article |
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The median initial CD4 super(+) count was 22 cells/ mu l (range, 1-311 cells/ mu l), and the median plasma HIV viral load was 5.1 log sub(10) copies/ml (range, 2.4-6.4 log sub(10) copies/ml). The fundus was examined monthly in patients with a history of CMV retinitis or an initial CD4 super(+) count <50 cells/ mu l and every 3 months in the other patients. Of patients with previously controlled CMV retinitis, 1 of 7 relapsed. In addition, 6 of 59 patients with a CD4 super(+) count <50 cells/ mu l and no history of CMV retinitis before starting PI therapy developed CMV retinitis. Of them, 3 had at least one relapse during follow-up. CD4 super(+) counts were <40 cells/ mu l at the time of primary or recurrent CMV retinitis, except in two cases (147 cells/ mu l and 203 cells/ mu l). In conclusion, the incidence of CMV retinitis was 0.091 per patient-year among study subjects with advanced HIV infection who were receiving HAART (95% confidence interval [CI], 0.037-0.145). The time to progression of CMV retinitis (mean, 215 days; 95% CI, 113-317 days) was longer than reported before widespread use of PIs.</description><identifier>ISSN: 1077-9450</identifier><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 2331-6993</identifier><identifier>DOI: 10.1097/00126334-199911010-00003</identifier><language>eng</language><publisher>New York, NY: Raven Press</publisher><subject>Biological and medical sciences ; CD4 antigen ; Cytomegalovirus ; Human cytomegalovirus ; Human immunodeficiency virus ; Human viral diseases ; Infectious diseases ; Medical sciences ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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The median initial CD4 super(+) count was 22 cells/ mu l (range, 1-311 cells/ mu l), and the median plasma HIV viral load was 5.1 log sub(10) copies/ml (range, 2.4-6.4 log sub(10) copies/ml). The fundus was examined monthly in patients with a history of CMV retinitis or an initial CD4 super(+) count <50 cells/ mu l and every 3 months in the other patients. Of patients with previously controlled CMV retinitis, 1 of 7 relapsed. In addition, 6 of 59 patients with a CD4 super(+) count <50 cells/ mu l and no history of CMV retinitis before starting PI therapy developed CMV retinitis. Of them, 3 had at least one relapse during follow-up. CD4 super(+) counts were <40 cells/ mu l at the time of primary or recurrent CMV retinitis, except in two cases (147 cells/ mu l and 203 cells/ mu l). In conclusion, the incidence of CMV retinitis was 0.091 per patient-year among study subjects with advanced HIV infection who were receiving HAART (95% confidence interval [CI], 0.037-0.145). The time to progression of CMV retinitis (mean, 215 days; 95% CI, 113-317 days) was longer than reported before widespread use of PIs.</description><subject>Biological and medical sciences</subject><subject>CD4 antigen</subject><subject>Cytomegalovirus</subject><subject>Human cytomegalovirus</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LABETOULLE, M</creatorcontrib><creatorcontrib>GOUJARD, C</creatorcontrib><creatorcontrib>FRAU, E</creatorcontrib><creatorcontrib>ROGIER, H</creatorcontrib><creatorcontrib>NIESSEN, F</creatorcontrib><creatorcontrib>FURLAN, V</creatorcontrib><creatorcontrib>LANTZ, O</creatorcontrib><creatorcontrib>LECOINTE, D</creatorcontrib><creatorcontrib>DELFRAISSY, J.-F</creatorcontrib><creatorcontrib>OFFRET, H</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LABETOULLE, M</au><au>GOUJARD, C</au><au>FRAU, E</au><au>ROGIER, H</au><au>NIESSEN, F</au><au>FURLAN, V</au><au>LANTZ, O</au><au>LECOINTE, D</au><au>DELFRAISSY, J.-F</au><au>OFFRET, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytomegalovirus retinitis in advanced HIV-infected patients treated with protease inhibitors : Incidence and outcome over 2 years</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><date>1999-11-01</date><risdate>1999</risdate><volume>22</volume><issue>3</issue><spage>228</spage><epage>234</epage><pages>228-234</pages><issn>1077-9450</issn><issn>1525-4135</issn><eissn>2331-6993</eissn><abstract>We prospectively studied the incidence of cytomegalovirus (CMV) retinitis in 93 patients treated with highly active antiretroviral therapy (HAART) containing a protease inhibitor (PI), during a median follow-up period of 24 months. The median initial CD4 super(+) count was 22 cells/ mu l (range, 1-311 cells/ mu l), and the median plasma HIV viral load was 5.1 log sub(10) copies/ml (range, 2.4-6.4 log sub(10) copies/ml). The fundus was examined monthly in patients with a history of CMV retinitis or an initial CD4 super(+) count <50 cells/ mu l and every 3 months in the other patients. Of patients with previously controlled CMV retinitis, 1 of 7 relapsed. In addition, 6 of 59 patients with a CD4 super(+) count <50 cells/ mu l and no history of CMV retinitis before starting PI therapy developed CMV retinitis. Of them, 3 had at least one relapse during follow-up. CD4 super(+) counts were <40 cells/ mu l at the time of primary or recurrent CMV retinitis, except in two cases (147 cells/ mu l and 203 cells/ mu l). In conclusion, the incidence of CMV retinitis was 0.091 per patient-year among study subjects with advanced HIV infection who were receiving HAART (95% confidence interval [CI], 0.037-0.145). The time to progression of CMV retinitis (mean, 215 days; 95% CI, 113-317 days) was longer than reported before widespread use of PIs.</abstract><cop>New York, NY</cop><pub>Raven Press</pub><doi>10.1097/00126334-199911010-00003</doi><tpages>7</tpages></addata></record> |
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| issn | 1077-9450 1525-4135 2331-6993 |
| language | eng |
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| source | Journals@Ovid LWW Legacy Archive; Free E- Journals; Journals@Ovid Complete |
| subjects | Biological and medical sciences CD4 antigen Cytomegalovirus Human cytomegalovirus Human immunodeficiency virus Human viral diseases Infectious diseases Medical sciences Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Cytomegalovirus retinitis in advanced HIV-infected patients treated with protease inhibitors : Incidence and outcome over 2 years |
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