Response Properties of Single Auditory Nerve Fibers in the Mouse
1 Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary and 2 Department of Otology and Laryngology, Harvard Medical School, Boston; and 3 Program in Speech and Hearing Bioscience and Technology, Division of Health Science and Technology, Harvard/Massachusetts Institute of Technology, Cambri...
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| Veröffentlicht in: | Journal of neurophysiology 2005-01, Vol.93 (1), p.557-569 |
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| creator | Taberner, Annette M Liberman, M. Charles |
| description | 1 Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary and 2 Department of Otology and Laryngology, Harvard Medical School, Boston; and 3 Program in Speech and Hearing Bioscience and Technology, Division of Health Science and Technology, Harvard/Massachusetts Institute of Technology, Cambridge, Massachusetts
Submitted 2 June 2004;
accepted in final form 21 September 2004
The availability of transgenic and mutant lines makes the mouse a valuable model for study of the inner ear, and a powerful window into cochlear function can be obtained by recordings from single auditory nerve (AN) fibers. This study provides the first systematic description of spontaneous and sound-evoked discharge properties of AN fibers in mouse, specifically in CBA/CaJ and C57BL/6 strains, both commonly used in auditory research. Response properties of 196 AN fibers from CBA/CaJ and 58 from C57BL/6 were analyzed, including spontaneous rates (SR), tuning curves, rate versus level functions, dynamic range, response adaptation, phase-locking, and the relation between SR and these response properties. The only significant interstrain difference was the elevation of high-frequency thresholds in C57BL/6. In general, mouse AN fibers showed similar responses to other mammals: sharpness of tuning increased with characteristic frequency, which ranged from 2.5 to 70 kHz; SRs ranged from 0 to 120 sp/s, and fibers with low SR ( |
| doi_str_mv | 10.1152/jn.00574.2004 |
| format | Article |
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Submitted 2 June 2004;
accepted in final form 21 September 2004
The availability of transgenic and mutant lines makes the mouse a valuable model for study of the inner ear, and a powerful window into cochlear function can be obtained by recordings from single auditory nerve (AN) fibers. This study provides the first systematic description of spontaneous and sound-evoked discharge properties of AN fibers in mouse, specifically in CBA/CaJ and C57BL/6 strains, both commonly used in auditory research. Response properties of 196 AN fibers from CBA/CaJ and 58 from C57BL/6 were analyzed, including spontaneous rates (SR), tuning curves, rate versus level functions, dynamic range, response adaptation, phase-locking, and the relation between SR and these response properties. The only significant interstrain difference was the elevation of high-frequency thresholds in C57BL/6. In general, mouse AN fibers showed similar responses to other mammals: sharpness of tuning increased with characteristic frequency, which ranged from 2.5 to 70 kHz; SRs ranged from 0 to 120 sp/s, and fibers with low SR (<1 sp/s) had higher thresholds, and wider dynamic ranges than fibers with high SR. Dynamic ranges for mouse high-SR fibers were smaller (<20 dB) than those seen in other mammals. Phase-locking was seen for tone frequencies <4 kHz. Maximum synchronization indices were lower than those in cat but similar to those found in guinea pig.
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Submitted 2 June 2004;
accepted in final form 21 September 2004
The availability of transgenic and mutant lines makes the mouse a valuable model for study of the inner ear, and a powerful window into cochlear function can be obtained by recordings from single auditory nerve (AN) fibers. This study provides the first systematic description of spontaneous and sound-evoked discharge properties of AN fibers in mouse, specifically in CBA/CaJ and C57BL/6 strains, both commonly used in auditory research. Response properties of 196 AN fibers from CBA/CaJ and 58 from C57BL/6 were analyzed, including spontaneous rates (SR), tuning curves, rate versus level functions, dynamic range, response adaptation, phase-locking, and the relation between SR and these response properties. The only significant interstrain difference was the elevation of high-frequency thresholds in C57BL/6. In general, mouse AN fibers showed similar responses to other mammals: sharpness of tuning increased with characteristic frequency, which ranged from 2.5 to 70 kHz; SRs ranged from 0 to 120 sp/s, and fibers with low SR (<1 sp/s) had higher thresholds, and wider dynamic ranges than fibers with high SR. Dynamic ranges for mouse high-SR fibers were smaller (<20 dB) than those seen in other mammals. Phase-locking was seen for tone frequencies <4 kHz. Maximum synchronization indices were lower than those in cat but similar to those found in guinea pig.
Address for reprint requests and other correspondence: M. C. Liberman, Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St., Boston, MA 02114 (E-mail; mcl{at}epl.meei.harvard.edu )</description><subject>Acoustic Stimulation - methods</subject><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Auditory Threshold - physiology</subject><subject>Cats</subject><subject>Chinchilla - physiology</subject><subject>Cochlear Nucleus - physiology</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Gerbillinae - physiology</subject><subject>Guinea Pigs</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Models, Statistical</subject><subject>Nerve Fibers - physiology</subject><subject>Nonlinear Dynamics</subject><subject>Rats</subject><subject>Reaction Time - physiology</subject><subject>Species Specificity</subject><subject>Time Factors</subject><subject>Vestibulocochlear Nerve - physiology</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElPwzAQRi0EgrIcuSKfuKWMtzi5gRAFJDaxnK0sk9ZVGgc7AfrvSaGIE-I0o9Gbb0aPkEMGY8YUP5k3YwCl5ZgDyA0yGmY8YipNNskIYOgFaL1DdkOYA4BWwLfJDlNSxQnIETl9xNC6JiB98K5F31kM1FX0yTbTGulZX9rO-SW9Q_-GdGJz9IHahnYzpLeuD7hPtqqsDniwrnvkZXLxfH4V3dxfXp-f3USFgriLMpUWOUsRlealYBWkpS51gSKJYwk8jkWsi7TiqcRCghYqk5VGjjnqvMwqJfbI8Xdu691rj6EzCxsKrOusweEPE2vBkxTkvyDTSgBTyQBG32DhXQgeK9N6u8j80jAwK7dm3pgvt2blduCP1sF9vsDyl17L_L08s9PZu_Vo2tkyWFe76XKVlQrDjFJ6APnf4KSv62f86IaNnwXTlpX4BKmKk4g</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Taberner, Annette M</creator><creator>Liberman, M. Charles</creator><general>Am Phys Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>Response Properties of Single Auditory Nerve Fibers in the Mouse</title><author>Taberner, Annette M ; Liberman, M. Charles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-a59cb19ee572d31f09d7d7ce386640266367c9f294ec40735a4f7e2ebe7bdaf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acoustic Stimulation - methods</topic><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Auditory Threshold - physiology</topic><topic>Cats</topic><topic>Chinchilla - physiology</topic><topic>Cochlear Nucleus - physiology</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Gerbillinae - physiology</topic><topic>Guinea Pigs</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Models, Statistical</topic><topic>Nerve Fibers - physiology</topic><topic>Nonlinear Dynamics</topic><topic>Rats</topic><topic>Reaction Time - physiology</topic><topic>Species Specificity</topic><topic>Time Factors</topic><topic>Vestibulocochlear Nerve - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taberner, Annette M</creatorcontrib><creatorcontrib>Liberman, M. Charles</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taberner, Annette M</au><au>Liberman, M. Charles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response Properties of Single Auditory Nerve Fibers in the Mouse</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>93</volume><issue>1</issue><spage>557</spage><epage>569</epage><pages>557-569</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><abstract>1 Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary and 2 Department of Otology and Laryngology, Harvard Medical School, Boston; and 3 Program in Speech and Hearing Bioscience and Technology, Division of Health Science and Technology, Harvard/Massachusetts Institute of Technology, Cambridge, Massachusetts
Submitted 2 June 2004;
accepted in final form 21 September 2004
The availability of transgenic and mutant lines makes the mouse a valuable model for study of the inner ear, and a powerful window into cochlear function can be obtained by recordings from single auditory nerve (AN) fibers. This study provides the first systematic description of spontaneous and sound-evoked discharge properties of AN fibers in mouse, specifically in CBA/CaJ and C57BL/6 strains, both commonly used in auditory research. Response properties of 196 AN fibers from CBA/CaJ and 58 from C57BL/6 were analyzed, including spontaneous rates (SR), tuning curves, rate versus level functions, dynamic range, response adaptation, phase-locking, and the relation between SR and these response properties. The only significant interstrain difference was the elevation of high-frequency thresholds in C57BL/6. In general, mouse AN fibers showed similar responses to other mammals: sharpness of tuning increased with characteristic frequency, which ranged from 2.5 to 70 kHz; SRs ranged from 0 to 120 sp/s, and fibers with low SR (<1 sp/s) had higher thresholds, and wider dynamic ranges than fibers with high SR. Dynamic ranges for mouse high-SR fibers were smaller (<20 dB) than those seen in other mammals. Phase-locking was seen for tone frequencies <4 kHz. Maximum synchronization indices were lower than those in cat but similar to those found in guinea pig.
Address for reprint requests and other correspondence: M. C. Liberman, Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St., Boston, MA 02114 (E-mail; mcl{at}epl.meei.harvard.edu )</abstract><cop>United States</cop><pub>Am Phys Soc</pub><pmid>15456804</pmid><doi>10.1152/jn.00574.2004</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acoustic Stimulation - methods Action Potentials - physiology Animals Auditory Threshold - physiology Cats Chinchilla - physiology Cochlear Nucleus - physiology Dose-Response Relationship, Radiation Gerbillinae - physiology Guinea Pigs Mice Mice, Inbred C57BL Mice, Inbred CBA Models, Statistical Nerve Fibers - physiology Nonlinear Dynamics Rats Reaction Time - physiology Species Specificity Time Factors Vestibulocochlear Nerve - physiology |
| title | Response Properties of Single Auditory Nerve Fibers in the Mouse |
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