Upregulation of lncRNA MEG3 promotes hepatic insulin resistance via increasing FoxO1 expression

Hepatic insulin resistance is a major characteristic of type 2 diabetes mellitus. LncRNA MEG3 has been shown to correlate to hepatic glucose production; however, the underlying mechanism remains unclear. This study aims to investigate the role of MEG3 in hepatic insulin resistance. High-fat diet mic...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-01, Vol.469 (2), p.319-325
Hauptverfasser:	Zhu, Xiang, Wu, Yuan-Bo, Zhou, Jian, Kang, Dong-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism FoxO1 Hepatic insulin resistance Insulin Resistance Liver - metabolism lncRNA MEG3 Male Mice Mice, Inbred C57BL Obesity - metabolism Primary hepatocytes RNA, Long Noncoding - metabolism Up-Regulation
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