uPA Attenuated LPS-induced Inflammatory Osteoclastogenesis through the Plasmin/PAR-1/Ca(2+)/CaMKK/AMPK Axis

Chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis-caused bone destruction, results from an increase of bone-resorbing osteoclasts (OCs) induced by inflammation. However, the detailed mechanisms underlying this disorder remain unclear. We herein investigated that the effec...

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Veröffentlicht in:	International journal of biological sciences 2016, Vol.12 (1), p.63-71
Hauptverfasser:	Kanno, Yosuke, Ishisaki, Akira, Kawashita, Eri, Kuretake, Hiromi, Ikeda, Kanako, Matsuo, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism Cell Differentiation - drug effects Cell Line Fibrinolysin - metabolism Lipopolysaccharides - pharmacology Mice Mitogen-Activated Protein Kinases - metabolism Osteoclasts - cytology Osteoclasts - drug effects Receptor, PAR-1 - metabolism Signal Transduction - drug effects Urokinase-Type Plasminogen Activator - metabolism Urokinase-Type Plasminogen Activator - pharmacology
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