Development and characterization of sorafenib-loaded PLGA nanoparticles for the systemic treatment of liver fibrosis

Sorafenib is a tyrosine kinase inhibitor that has recently been shown to be a potential antifibrotic agent. However, a narrow therapeutic window limits the clinical use and therapeutic efficacy of sorafenib. Herein, we have developed and optimized nanoparticle (NP) formulations prepared from a mixtu...

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