Comparison of enzyme kinetics of warfarin analyzed by LC–MS/MS QTrap and differential mobility spectrometry

•This work is the first to separate all the six hydroxylated metabolites of warfarin including 3′,4′,6,7,8,10-hydroxy warfarin, and the parent in single run.•This manuscript reports low limit of quantitation of 1nM for all analytes, previously reported LLOQs were significantly higher.•This manuscrip...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2016-01, Vol.1008, p.164-173
Hauptverfasser:	Shaik, Abdul Naveed, Grater, Richard, Lulla, Mukesh, Williams, David A., Gan, Lawrence L., Bohnert, Tonika, LeDuc, Barbara W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - pharmacokinetics Calibration Chromatography, Liquid - methods Cytochrome P-450 CYP2C9 - metabolism Cytochrome P-450 CYP3A - metabolism Differential mobility spectroscopy (DMS) Human liver microsomes Humans Hydroxywarfarin Ketoconazole LC–MS/MS Method validation QTrap Reproducibility of Results Substrate kinetics Sulfaphenazole Tandem Mass Spectrometry - methods Warfarin Warfarin - pharmacokinetics
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