SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery

Mutations in the Fe-S cluster-containing SDHB subunit of succinate dehydrogenase cause familial cancer syndromes. Recently the tripeptide motif L(I)YR was identified in the Fe-S recipient protein SDHB, to which the cochaperone HSC20 binds. In order to characterize the metabolic basis of SDH-deficien...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2016-01, Vol.108 (1), p.djv287
Hauptverfasser:	Saxena, Neetu, Maio, Nunziata, Crooks, Daniel R, Ricketts, Christopher J, Yang, Youfeng, Wei, Ming-Hui, Fan, Teresa W-M, Lane, Andrew N, Sourbier, Carole, Singh, Anamika, Killian, J Keith, Meltzer, Paul S, Vocke, Cathy D, Rouault, Tracey A, Linehan, W Marston
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors - metabolism Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Cell Line, Tumor CpG Islands - genetics DNA Methylation Germ-Line Mutation Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Iron-Sulfur Proteins - metabolism Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Molecular Chaperones - metabolism Mutation Mutation, Missense Phenotype Point Mutation Succinate Dehydrogenase - deficiency Succinate Dehydrogenase - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!