Controlled release of osteopontin and interleukin-10 from modified endovascular coil promote cerebral aneurysm healing

Abstract Cerebral aneurysm is a bulging of the artery inside the brain that results from a weakened or thin area of the artery wall. Ruptured cerebral aneurysm could lead to serious brain damage or even death, thus the proper treatment is essential. Compared with the conventional microsurgical clipp...

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Veröffentlicht in:	Journal of the neurological sciences 2016-01, Vol.360, p.13-17
Hauptverfasser:	Chen, Jingyi, Yang, Lijun, Chen, Yan, Zhang, Gengshen, Fan, Zheneng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cerebral aneurysm Coated Materials, Biocompatible Disease Models, Animal Embolization, Therapeutic - methods Endovascular coiling Endovascular Procedures - methods Female IL-10 Interleukin-10 - administration & dosage Interleukin-10 - therapeutic use Intracranial Aneurysm - drug therapy Intracranial Aneurysm - therapy Male Matrix Metalloproteinase 9 - administration & dosage Matrix Metalloproteinase 9 - therapeutic use MMP-9 Neurology Osteopontin Osteopontin - administration & dosage Osteopontin - therapeutic use Rats Rats, Sprague-Dawley Treatment Outcome
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