Metabolism and Toxicity of Trichloroethylene and S-(1,2-Dichlorovinyl)-L-Cysteine in Freshly Isolated Human Proximal Tubular Cells

Trichloroethylene (Tri) caused modest cytotoxicity in freshly isolated human proximal tubular (hPT) cells, as assessed by significant decreases in lactate dehydrogenase (LDH) activity after 1 h of exposure to 500 μM Tri. Oxidative metabolism of Tri by cytochrome P-450 to form chloral hydrate (CH) wa...

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Veröffentlicht in:	Toxicological sciences 2000-02, Vol.53 (2), p.458-466
Hauptverfasser:	Cummings, Brian S., Lash, Lawrence H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aminooxyacetic Acid - pharmacology Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chloral Hydrate - metabolism Cysteine - analogs & derivatives Cysteine - metabolism Cysteine - toxicity cytochrome P-450 Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Enzyme Inhibitors - pharmacology Female Glutathione - metabolism glutathione conjugation human kidney Humans Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism L-Lactate Dehydrogenase - antagonists & inhibitors L-Lactate Dehydrogenase - metabolism Male Medical sciences Metyrapone - pharmacology Microsomes - drug effects Microsomes - metabolism Middle Aged proximal tubular cells S-1,2-Dichlorovinyl-L-cysteine Solvents Toxicology trichloroethylene Trichloroethylene - metabolism Trichloroethylene - toxicity
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