The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3' kinase

Scatter factor (SF) [aka. hepatocyte growth factor (HGF)] (designated HGF/SF) is a multifunctional cytokine that stimulates tumor cell invasion and angiogenesis. We recently reported that HGF/SF protects epithelial and carcinoma cells against cytotoxicity from DNA-damaging agents and that HGF/SF-med...

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Veröffentlicht in:	Oncogene 2000-04, Vol.19 (18), p.2212-2223
Hauptverfasser:	SAIJUN FAN, YONG XIAN MA, WANG, J.-A, YUAN, R.-Q, QINGHUI MENG, YIJAN CAO, LATERRA, J. J, GOLDBERG, I. D, ROSEN, E. M
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Antimutagenic Agents - pharmacology Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Bcl-x protein Bcl-xL gene Biological and medical sciences BRCA1 Protein Breast cancer Breast Neoplasms c-Akt protein Cell physiology Cell survival Chemoresistance Cytokines Cytotoxicity Deoxyribonucleic acid DNA DNA damage DNA repair DNA Repair - drug effects Dose-Response Relationship, Radiation Doxorubicin - pharmacology Female Fundamental and applied biological sciences. Psychology Gamma Rays Growth factors Hepatocyte growth factor Hepatocyte Growth Factor - pharmacology Humans Inositol Kinases Male Medicine Molecular and cellular biology Mutagens - pharmacology Oncology Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Prostatic Neoplasms Protein kinase protein kinase B Protein-Serine-Threonine Kinases Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-bcl-2 Radiation Research centers Signal Transduction Tumor Cells, Cultured Tumors Wortmannin γ Radiation
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