Modulation of daunorubicin toxicity by liposomal encapsulation and use of specific inhibitors in vitro

Anthracyclines serve as a valuable tool in chemotherapy, but their usefulness is often limited by the occurrence of resistance mechanisms in tumor cells. Resistance of tumor cells is a multifactorial event, where several mechanisms act concurrently, including drug efflux and enzymatic drug inactivat...

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Veröffentlicht in:Toxicology (Amsterdam) 2000-04, Vol.144 (1), p.189-195
Hauptverfasser: Iffert, Tanja, Soldan, Michael, Moeller, Anja, Maser, Edmund
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Sprache:eng
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