Development and characterization of bio-derived polyhydroxyalkanoate nanoparticles as a delivery system for hydrophobic photodynamic therapy agents

In this study, we developed and investigated nanoparticles of biologically-derived, biodegradable polyhydroxyalkanoates (PHAs) as carriers of a hydrophobic photosensitizer, 5,10,15,20-Tetrakis(4-hydroxy-phenyl)-21 H , 23 H -porphine (pTHPP) for photodynamic therapy (PDT). Three PHA variants; polyhyd...

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Veröffentlicht in:	Journal of materials science. Materials in medicine 2016-02, Vol.27 (2), p.40-40, Article 40
Hauptverfasser:	Pramual, Sasivimon, Assavanig, Apinya, Bergkvist, Magnus, Batt, Carl A., Sunintaboon, Panya, Lirdprapamongkol, Kriengsak, Svasti, Jisnuson, Niamsiri, Nuttawee
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products - chemistry Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Ceramics Chemistry and Materials Science Composites Cupriavidus necator Delivery Systems Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Compounding Drug Delivery Systems Drug Stability Excipients - chemistry Glass HT29 Cells Humans Hydrophobic and Hydrophilic Interactions Materials Science Materials Testing Nanoparticles - chemistry Natural Materials Photochemotherapy - methods Photosensitizing Agents - administration & dosage Photosensitizing Agents - pharmacokinetics Polyhydroxyalkanoates - chemical synthesis Polyhydroxyalkanoates - chemistry Polyhydroxyalkanoates - pharmacokinetics Polymer Sciences Polyvinyl Alcohol - chemistry Porphyrins - administration & dosage Porphyrins - pharmacokinetics Regenerative Medicine/Tissue Engineering Surfaces and Interfaces Thin Films
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