Assessment of osteoinduction using a porous hydroxyapatite coating prepared by micro-arc oxidation on a new titanium alloy

Abstract Surface modification and material improvement is now an important way to improve the osseointegration between bone and uncemented prothesis. The purpose of this study was to investigate the bone ingrowth potential of porous hydroxyapatite (HA) coatings prepared by micro-arc oxidation (MAO)...

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Veröffentlicht in:International journal of surgery (London, England) England), 2015-12, Vol.24 (Pt A), p.51-56
Hauptverfasser: Jing, Wensen, Zhang, Minghua, Jin, Lei, Zhao, Jian, Gao, Qing, Ren, Min, Fan, Qingyu
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container_end_page 56
container_issue Pt A
container_start_page 51
container_title International journal of surgery (London, England)
container_volume 24
creator Jing, Wensen
Zhang, Minghua
Jin, Lei
Zhao, Jian
Gao, Qing
Ren, Min
Fan, Qingyu
description Abstract Surface modification and material improvement is now an important way to improve the osseointegration between bone and uncemented prothesis. The purpose of this study was to investigate the bone ingrowth potential of porous hydroxyapatite (HA) coatings prepared by micro-arc oxidation (MAO) on Ti–3Zr–2Sn–3Mo–25Nb, a new titanium alloy. HA-coated specimens were implanted in the left proximal femoral medullary canal of beagles for 4, 12, and 24 weeks, and uncoated specimens were implanted in the right as a control. The surface morphology and phase composition were investigated with environmental scanning electron microscopy and X-ray diffractometry. The bone ingrowth was assessed by histomorphometry. A pull-out test was performed to assess the mechanical performance of the bone–implant interface. A porous coating was well prepared on the new titanium alloy by using the MAO method. The bone-to-implant contact was significantly higher for the HA-coated group compared to that in the uncoated group. Mechanical tests showed that the HA-coated group had significantly higher maximum force at the bone–implant interface compared to the uncoated specimens. MAO is a suitable coating approach for this new titanium alloy. The HA coating prepared by this approach can significantly promote bone ingrowth and the mechanical performance of the bone–implant interface.
doi_str_mv 10.1016/j.ijsu.2015.08.030
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The purpose of this study was to investigate the bone ingrowth potential of porous hydroxyapatite (HA) coatings prepared by micro-arc oxidation (MAO) on Ti–3Zr–2Sn–3Mo–25Nb, a new titanium alloy. HA-coated specimens were implanted in the left proximal femoral medullary canal of beagles for 4, 12, and 24 weeks, and uncoated specimens were implanted in the right as a control. The surface morphology and phase composition were investigated with environmental scanning electron microscopy and X-ray diffractometry. The bone ingrowth was assessed by histomorphometry. A pull-out test was performed to assess the mechanical performance of the bone–implant interface. A porous coating was well prepared on the new titanium alloy by using the MAO method. The bone-to-implant contact was significantly higher for the HA-coated group compared to that in the uncoated group. Mechanical tests showed that the HA-coated group had significantly higher maximum force at the bone–implant interface compared to the uncoated specimens. MAO is a suitable coating approach for this new titanium alloy. 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Mechanical tests showed that the HA-coated group had significantly higher maximum force at the bone–implant interface compared to the uncoated specimens. MAO is a suitable coating approach for this new titanium alloy. 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source MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals
subjects Alloys
Animals
Arthroplasty, Replacement, Hip - instrumentation
Coated Materials, Biocompatible - chemistry
Coating
Disease Models, Animal
Dogs
Durapatite - chemistry
Female
Hydroxyapatite
Male
Micro-arc oxidation
Microscopy, Electron, Scanning
Osseointegration - drug effects
Porosity
Prostheses and Implants
Surface Properties
Surgery
Titanium
Titanium alloy
title Assessment of osteoinduction using a porous hydroxyapatite coating prepared by micro-arc oxidation on a new titanium alloy
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