Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages

•Mice deficient in G-CSF receptor were susceptible to DSS-induced acute colitis.•G-CSF enhanced generation of unique M2-like macrophages from bone marrow cells in vitro.•G-CSF enhanced homing of the macrophages into the intestine.•Adoptive transfer of the G-CSF-exposed macrophages reduced DSS-induce...

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