Coordinated Changes of Adenylate Energy Charge and ATP/ADP: Use in Ecotoxicological Studies
The coordinated variations of the adenylate energy charge and ATP/ADP ratio were modeled and a function that depends on the numerical value of the adenylate kinase-catalyzed reaction has been derived. The model allows sensitive detection of the effects of xenobiotics on adenylate kinase and its cell...
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| Veröffentlicht in: | Ecotoxicology and environmental safety 2000-05, Vol.46 (1), p.23-28 |
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| container_title | Ecotoxicology and environmental safety |
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| creator | Thébault, M.T. Raffin, J.P. Picado, A.M. Mendonça, E. Skorkowski, E.F. Le Gal, Y. |
| description | The coordinated variations of the adenylate energy charge and ATP/ADP ratio were modeled and a function that depends on the numerical value of the adenylate kinase-catalyzed reaction has been derived. The model allows sensitive detection of the effects of xenobiotics on adenylate kinase and its cellular environment and offers a robust estimation of the direct or indirect effects of pollutants on the adenylate kinase system: data obtained in laboratory studies on shrimp exposed to cadmium and in field studies on oysters either exposed to polychloro-biphenyl compounds or located in a heavily polluted area indicate that xenobiotics affect the adenylate kinase reaction directly or by changing its cellular environment. These results demonstrate that application of the model to the treatment of ecotoxicological data allows detection of energetic changes that would have been missed by simple analysis of the usual energetic parameters, and should overcome problems encountered in using energetic parameters during assessment of pollution monitoring. |
| doi_str_mv | 10.1006/eesa.1999.1870 |
| format | Article |
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The model allows sensitive detection of the effects of xenobiotics on adenylate kinase and its cellular environment and offers a robust estimation of the direct or indirect effects of pollutants on the adenylate kinase system: data obtained in laboratory studies on shrimp exposed to cadmium and in field studies on oysters either exposed to polychloro-biphenyl compounds or located in a heavily polluted area indicate that xenobiotics affect the adenylate kinase reaction directly or by changing its cellular environment. 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The model allows sensitive detection of the effects of xenobiotics on adenylate kinase and its cellular environment and offers a robust estimation of the direct or indirect effects of pollutants on the adenylate kinase system: data obtained in laboratory studies on shrimp exposed to cadmium and in field studies on oysters either exposed to polychloro-biphenyl compounds or located in a heavily polluted area indicate that xenobiotics affect the adenylate kinase reaction directly or by changing its cellular environment. These results demonstrate that application of the model to the treatment of ecotoxicological data allows detection of energetic changes that would have been missed by simple analysis of the usual energetic parameters, and should overcome problems encountered in using energetic parameters during assessment of pollution monitoring.</description><subject>Adenosine Diphosphate - analysis</subject><subject>Adenosine Triphosphate - analysis</subject><subject>adenylate energy charge</subject><subject>adenylate kinase</subject><subject>Adenylate Kinase - metabolism</subject><subject>ADP</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>ATP/ADP</subject><subject>Biological and medical sciences</subject><subject>cadmium</subject><subject>Cadmium - toxicity</subject><subject>Decapoda (Crustacea) - drug effects</subject><subject>ecotoxicology</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Energy Metabolism - drug effects</subject><subject>Environmental Pollutants - toxicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>modelization</subject><subject>Mollusca - drug effects</subject><subject>PCB</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>Techniques</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1rGzEQhkVJaVy31xyDDqG3dUa70u4qN-O4HxBooMmpByGPZh2FtZRI61L_--5iQ3vpaWDmmZeZh7ELAQsBUF8TZbsQWuuFaBt4w2YCNBSlFPKMzUDIpqiVqM7Z-5yfAaACpd6xcwEtKN3qGfu5ijE5H-xAjq-ebNhS5rHjS0fh0I9dvg6UtodplrbEbXB8-XB_vby9v-GPmbgPfI1xiL89xj5uPdqe_xj2zlP-wN52ts_08VTn7PHz-mH1tbj7_uXbanlXoAQYilqIUgupCBvZaW1b5RxgJZtaQIUVUiehJF1T4zZlU200EiqooVTVBqFuqzn7dMx9SfF1T3kwO5-R-t4GivtsRKNK2Yz4nC2OIKaYc6LOvCS_s-lgBJhJp5l0mkmnmXSOC5en5P1mR-4f_OhvBK5OgM3j512yAX3-y8nRuJ4ubI8YjRp-eUomo6eA5HwiHIyL_n8n_AF51I8H</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>Thébault, M.T.</creator><creator>Raffin, J.P.</creator><creator>Picado, A.M.</creator><creator>Mendonça, E.</creator><creator>Skorkowski, E.F.</creator><creator>Le Gal, Y.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20000501</creationdate><title>Coordinated Changes of Adenylate Energy Charge and ATP/ADP: Use in Ecotoxicological Studies</title><author>Thébault, M.T. ; Raffin, J.P. ; Picado, A.M. ; Mendonça, E. ; Skorkowski, E.F. ; Le Gal, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-61129145ec74f99a85dd0c3476103c3cef402e96e7db273b9cec5060253bc0683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adenosine Diphosphate - analysis</topic><topic>Adenosine Triphosphate - analysis</topic><topic>adenylate energy charge</topic><topic>adenylate kinase</topic><topic>Adenylate Kinase - metabolism</topic><topic>ADP</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>ATP/ADP</topic><topic>Biological and medical sciences</topic><topic>cadmium</topic><topic>Cadmium - toxicity</topic><topic>Decapoda (Crustacea) - drug effects</topic><topic>ecotoxicology</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Energy Metabolism - drug effects</topic><topic>Environmental Pollutants - toxicity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>modelization</topic><topic>Mollusca - drug effects</topic><topic>PCB</topic><topic>Polychlorinated Biphenyls - toxicity</topic><topic>Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thébault, M.T.</creatorcontrib><creatorcontrib>Raffin, J.P.</creatorcontrib><creatorcontrib>Picado, A.M.</creatorcontrib><creatorcontrib>Mendonça, E.</creatorcontrib><creatorcontrib>Skorkowski, E.F.</creatorcontrib><creatorcontrib>Le Gal, Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thébault, M.T.</au><au>Raffin, J.P.</au><au>Picado, A.M.</au><au>Mendonça, E.</au><au>Skorkowski, E.F.</au><au>Le Gal, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coordinated Changes of Adenylate Energy Charge and ATP/ADP: Use in Ecotoxicological Studies</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>46</volume><issue>1</issue><spage>23</spage><epage>28</epage><pages>23-28</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><coden>EESADV</coden><abstract>The coordinated variations of the adenylate energy charge and ATP/ADP ratio were modeled and a function that depends on the numerical value of the adenylate kinase-catalyzed reaction has been derived. The model allows sensitive detection of the effects of xenobiotics on adenylate kinase and its cellular environment and offers a robust estimation of the direct or indirect effects of pollutants on the adenylate kinase system: data obtained in laboratory studies on shrimp exposed to cadmium and in field studies on oysters either exposed to polychloro-biphenyl compounds or located in a heavily polluted area indicate that xenobiotics affect the adenylate kinase reaction directly or by changing its cellular environment. 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| subjects | Adenosine Diphosphate - analysis Adenosine Triphosphate - analysis adenylate energy charge adenylate kinase Adenylate Kinase - metabolism ADP Animal, plant and microbial ecology Animals Applied ecology ATP/ADP Biological and medical sciences cadmium Cadmium - toxicity Decapoda (Crustacea) - drug effects ecotoxicology Ecotoxicology, biological effects of pollution Energy Metabolism - drug effects Environmental Pollutants - toxicity Fundamental and applied biological sciences. Psychology modelization Mollusca - drug effects PCB Polychlorinated Biphenyls - toxicity Techniques |
| title | Coordinated Changes of Adenylate Energy Charge and ATP/ADP: Use in Ecotoxicological Studies |
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