Evolutionary conservation in protein folding kinetics

The sequence and structural conservation of folding transition states have been predicted on theoretical grounds. Using homologous sequence alignments of proteins previously characterized via coupled mutagenesis/kinetics studies, we tested these predictions experimentally. Only one of the six approp...

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Veröffentlicht in:	Journal of molecular biology 2000-04, Vol.298 (2), p.303-312
Hauptverfasser:	Plaxco, Kevin W, Larson, Stefan, Ruczinski, Ingo, Riddle, David S, Thayer, Edward C, Buchwitz, Brian, Davidson, Alan R, Baker, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Conserved Sequence - genetics evolution Evolution, Molecular Kinetics Mutation - genetics nucleation-condensation phi-values Protein Conformation Protein Folding Proteins - chemistry Proteins - genetics Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid src Homology Domains Statistics as Topic Structure-Activity Relationship Thermodynamics
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