Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells

Glycation, a process that occurs endogenously and generates advanced glycation end products (AGEs), presents an important role in cases of neurodegeneration, as for instance Alzheimer's disease (AD). Methylglyoxal (MG), a dicarbonyl compound, is the most potent inducer of AGEs, whose levels hav...

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Veröffentlicht in:	Chemico-biological interactions 2015-12, Vol.242, p.396-406
Hauptverfasser:	de Oliveira, Marcos Roberto, Ferreira, Gustavo Costa, Schuck, Patrícia Fernanda, Dal Bosco, Simone Morelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Antioxidants - pharmacology Apoptosis - drug effects Carnosic acid Cell Line, Tumor Cytoprotection - drug effects Diterpenes, Abietane - pharmacology Humans Methylglyoxal Neuroblastoma - pathology Neurons - cytology Neurons - drug effects Neurons - enzymology Neurons - metabolism Neurotoxins - toxicity NF-E2-Related Factor 2 - metabolism Nrf2 Oxidation-Reduction - drug effects Oxidative stress Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Pyruvaldehyde - toxicity Signal Transduction - drug effects Time Factors
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