Identification of peptide inhibitors of penicillinase using a phage display library

There is a constant need to identify novel inhibitors to combat β-lactamase-mediated antibiotic resistance. In this study, we identify three penicillinase-binding peptides, P1 (DHIHRSYRGEFD), P2 (NIYTTPWGSNWS), and P3 (SHSLPASADLRR), using a phage display library. Surface plasmon resonance (SPR) is...

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Veröffentlicht in:	Analytical biochemistry 2016-02, Vol.494, p.4-9
Hauptverfasser:	Zou, Qiongjing, Yang, Kun-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibiotic resistance beta-Lactamase Inhibitors - chemistry beta-Lactamase Inhibitors - metabolism Enzyme inhibitor Hydrolysis Kinetics Penicillin G - metabolism Penicillinase Penicillinase - chemistry Penicillinase - metabolism Peptide inhibitor Peptide Library Phage display Protein Binding Spectrophotometry, Ultraviolet Substrate Specificity Surface Plasmon Resonance
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