Mechanisms of Protective Effect of Ramulus Mori Polysaccharides on Renal Injury in High-Fat Diet/Streptozotocin-Induced Diabetic Rats
Background: Diabetic nephropathy (DN) is the most important complication of diabetes and the most common cause of end-stage renal disease (ESRD). Aims: A recent study established that the Ramulus mori polysaccharides (RMP) exert antioxidant effects on DN in rats. Methods: The diabetic rats which ind...
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| Veröffentlicht in: | Cellular Physiology and Biochemistry 2015-01, Vol.37 (6), p.2125-2134 |
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| container_title | Cellular Physiology and Biochemistry |
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| creator | Li, Xi Wang, Ling Gao, Xingxin Li, Guoping Cao, Honghua Song, Dezhi Cai, Shuangqi Liang, Tao Zhang, Bo Du, Gang |
| description | Background: Diabetic nephropathy (DN) is the most important complication of diabetes and the most common cause of end-stage renal disease (ESRD). Aims: A recent study established that the Ramulus mori polysaccharides (RMP) exert antioxidant effects on DN in rats. Methods: The diabetic rats which induced by high-fat diet and streptozotocin injection were orally administered RMP by doses of 250, 500 and 1000 mg/kg daily for 8 weeks. The effects of RMP on hyperglycemia and other biochemical changes were examined in the sera and kidney tissues. Additionally, the pathological and ultrastructural changes and expressions of nuclear-factor kappa B (NF-κB) and transforming growth factor-ß1 (TGF-ß1) were assessed. Results: The results revealed that the serum levels of blood glucose, total cholesterol (TC) and triglycerides (TG) were significantly decreased by RMP. Furthermore, the blood urea nitrogen (BUN), serum creatinine (SCr) and 24-hour urine protein levels in the RMP-medicated rats were lower than those in untreated diabetic rats. Moreover, treatment of the DN rats with RMP normalized all biochemical changes, including the malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels in the serum and kidney tissues. In contrast, the protein expression levels of NF-κB and TGF-ß1, which were enhanced in the kidneys of DN rats, were reduced by RMP. Conclusion: These results suggest that RMP improving the renal function of diabeitc rats possibly via its ameliorating antioxidant activities. |
| doi_str_mv | 10.1159/000438570 |
| format | Article |
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Aims: A recent study established that the Ramulus mori polysaccharides (RMP) exert antioxidant effects on DN in rats. Methods: The diabetic rats which induced by high-fat diet and streptozotocin injection were orally administered RMP by doses of 250, 500 and 1000 mg/kg daily for 8 weeks. The effects of RMP on hyperglycemia and other biochemical changes were examined in the sera and kidney tissues. Additionally, the pathological and ultrastructural changes and expressions of nuclear-factor kappa B (NF-κB) and transforming growth factor-ß1 (TGF-ß1) were assessed. Results: The results revealed that the serum levels of blood glucose, total cholesterol (TC) and triglycerides (TG) were significantly decreased by RMP. Furthermore, the blood urea nitrogen (BUN), serum creatinine (SCr) and 24-hour urine protein levels in the RMP-medicated rats were lower than those in untreated diabetic rats. Moreover, treatment of the DN rats with RMP normalized all biochemical changes, including the malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels in the serum and kidney tissues. In contrast, the protein expression levels of NF-κB and TGF-ß1, which were enhanced in the kidneys of DN rats, were reduced by RMP. Conclusion: These results suggest that RMP improving the renal function of diabeitc rats possibly via its ameliorating antioxidant activities.</description><identifier>ISSN: 1015-8987</identifier><identifier>EISSN: 1421-9778</identifier><identifier>DOI: 10.1159/000438570</identifier><identifier>PMID: 26599870</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Antioxidant activities ; Blood Glucose - analysis ; Cholesterol - blood ; Complications and side effects ; Diabetes Mellitus, Experimental - complications ; Diabetes therapy ; Diabetic Nephropathies - complications ; Diabetic Nephropathies - physiopathology ; Diabetic Nephropathies - prevention & control ; Diabetic nephropathy ; Diet, High-Fat ; Health aspects ; Kidney - metabolism ; Kidney - physiopathology ; Male ; Mulberry ; NF-kappa B - metabolism ; Original Paper ; Oxidative Stress ; Patient outcomes ; Polysaccharides ; Polysaccharides - pharmacology ; Ramulus mori polysaccharides ; Rats ; Rats, Wistar ; Renoprotection ; Streptozocin ; Streptozocin - administration & dosage ; Transforming Growth Factor beta1 - metabolism ; Triglycerides - blood</subject><ispartof>Cellular Physiology and Biochemistry, 2015-01, Vol.37 (6), p.2125-2134</ispartof><rights>2015 The Author(s) Published by S. Karger AG, Basel</rights><rights>2015 The Author(s) Published by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2015 S. Karger AG</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-c16a634be0164055c29e9b9ce65189fe1ba108ceb0af4967be5aa4e013fde7873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,2096,27612,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26599870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xi</creatorcontrib><creatorcontrib>Wang, Ling</creatorcontrib><creatorcontrib>Gao, Xingxin</creatorcontrib><creatorcontrib>Li, Guoping</creatorcontrib><creatorcontrib>Cao, Honghua</creatorcontrib><creatorcontrib>Song, Dezhi</creatorcontrib><creatorcontrib>Cai, Shuangqi</creatorcontrib><creatorcontrib>Liang, Tao</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Du, Gang</creatorcontrib><title>Mechanisms of Protective Effect of Ramulus Mori Polysaccharides on Renal Injury in High-Fat Diet/Streptozotocin-Induced Diabetic Rats</title><title>Cellular Physiology and Biochemistry</title><addtitle>Cell Physiol Biochem</addtitle><description>Background: Diabetic nephropathy (DN) is the most important complication of diabetes and the most common cause of end-stage renal disease (ESRD). Aims: A recent study established that the Ramulus mori polysaccharides (RMP) exert antioxidant effects on DN in rats. Methods: The diabetic rats which induced by high-fat diet and streptozotocin injection were orally administered RMP by doses of 250, 500 and 1000 mg/kg daily for 8 weeks. The effects of RMP on hyperglycemia and other biochemical changes were examined in the sera and kidney tissues. Additionally, the pathological and ultrastructural changes and expressions of nuclear-factor kappa B (NF-κB) and transforming growth factor-ß1 (TGF-ß1) were assessed. Results: The results revealed that the serum levels of blood glucose, total cholesterol (TC) and triglycerides (TG) were significantly decreased by RMP. Furthermore, the blood urea nitrogen (BUN), serum creatinine (SCr) and 24-hour urine protein levels in the RMP-medicated rats were lower than those in untreated diabetic rats. Moreover, treatment of the DN rats with RMP normalized all biochemical changes, including the malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels in the serum and kidney tissues. In contrast, the protein expression levels of NF-κB and TGF-ß1, which were enhanced in the kidneys of DN rats, were reduced by RMP. Conclusion: These results suggest that RMP improving the renal function of diabeitc rats possibly via its ameliorating antioxidant activities.</description><subject>Animals</subject><subject>Antioxidant activities</subject><subject>Blood Glucose - analysis</subject><subject>Cholesterol - blood</subject><subject>Complications and side effects</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes therapy</subject><subject>Diabetic Nephropathies - complications</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic Nephropathies - prevention & control</subject><subject>Diabetic nephropathy</subject><subject>Diet, High-Fat</subject><subject>Health aspects</subject><subject>Kidney - metabolism</subject><subject>Kidney - physiopathology</subject><subject>Male</subject><subject>Mulberry</subject><subject>NF-kappa B - metabolism</subject><subject>Original Paper</subject><subject>Oxidative Stress</subject><subject>Patient outcomes</subject><subject>Polysaccharides</subject><subject>Polysaccharides - pharmacology</subject><subject>Ramulus mori polysaccharides</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renoprotection</subject><subject>Streptozocin</subject><subject>Streptozocin - administration & dosage</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><subject>Triglycerides - blood</subject><issn>1015-8987</issn><issn>1421-9778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNptkUFv1DAQhSMEoqVw4I5QJC70kNZO4iQ-lqWlK7ViVeAcTezx1ksSb20Habnzvzsly56QD555_t7zSJMkbzk741zIc8ZYWTSiZs-SY17mPJN13TynmnGRNbKpj5JXIWwYtbXMXyZHeSUkyew4-XOL6h5GG4aQOpOuvIuoov2F6aUxVD2JdzBM_RTSW-dtunL9LoAik7cayTSmdzhCny7HzeR3qR3Ta7u-z64gpp8txvNv0eM2ut8uOmXHbDnqSaGmN-gwWkXpMbxOXhjoA77Z3yfJj6vL74vr7Obrl-Xi4iZTguUxU7yCqig7ZLwqmRAqlyg7qbASvJEGeQecNQo7BqaUVd2hACiJLozGuqmLk2Q552oHm3br7QB-1zqw7V_B-XULnobqse06jqXQsjJYlIVh1AKg1g1UimpFWR_nrK13DxOG2A42KOx7GNFNoeW1yAvBq7wg9GxG10DJdjQuelB0NA5WuRGNJf2iKmrBClomGU5ng_IuBI_mMCtn7dPK28PKiX2_n2PqBtQH8t-OCfgwAz_Br9EfgMXq0xzRbrUh6t1_qf0vj1MSvKE</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Li, Xi</creator><creator>Wang, Ling</creator><creator>Gao, Xingxin</creator><creator>Li, Guoping</creator><creator>Cao, Honghua</creator><creator>Song, Dezhi</creator><creator>Cai, Shuangqi</creator><creator>Liang, Tao</creator><creator>Zhang, Bo</creator><creator>Du, Gang</creator><general>S. Karger AG</general><general>Cell Physiol Biochem Press GmbH & Co KG</general><scope>M--</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20150101</creationdate><title>Mechanisms of Protective Effect of Ramulus Mori Polysaccharides on Renal Injury in High-Fat Diet/Streptozotocin-Induced Diabetic Rats</title><author>Li, Xi ; Wang, Ling ; Gao, Xingxin ; Li, Guoping ; Cao, Honghua ; Song, Dezhi ; Cai, Shuangqi ; Liang, Tao ; Zhang, Bo ; Du, Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-c16a634be0164055c29e9b9ce65189fe1ba108ceb0af4967be5aa4e013fde7873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antioxidant activities</topic><topic>Blood Glucose - analysis</topic><topic>Cholesterol - blood</topic><topic>Complications and side effects</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes therapy</topic><topic>Diabetic Nephropathies - complications</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diabetic Nephropathies - prevention & control</topic><topic>Diabetic nephropathy</topic><topic>Diet, High-Fat</topic><topic>Health aspects</topic><topic>Kidney - metabolism</topic><topic>Kidney - physiopathology</topic><topic>Male</topic><topic>Mulberry</topic><topic>NF-kappa B - metabolism</topic><topic>Original Paper</topic><topic>Oxidative Stress</topic><topic>Patient outcomes</topic><topic>Polysaccharides</topic><topic>Polysaccharides - pharmacology</topic><topic>Ramulus mori polysaccharides</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Renoprotection</topic><topic>Streptozocin</topic><topic>Streptozocin - administration & dosage</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xi</creatorcontrib><creatorcontrib>Wang, Ling</creatorcontrib><creatorcontrib>Gao, Xingxin</creatorcontrib><creatorcontrib>Li, Guoping</creatorcontrib><creatorcontrib>Cao, Honghua</creatorcontrib><creatorcontrib>Song, Dezhi</creatorcontrib><creatorcontrib>Cai, Shuangqi</creatorcontrib><creatorcontrib>Liang, Tao</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Du, Gang</creatorcontrib><collection>Karger Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cellular Physiology and Biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xi</au><au>Wang, Ling</au><au>Gao, Xingxin</au><au>Li, Guoping</au><au>Cao, Honghua</au><au>Song, Dezhi</au><au>Cai, Shuangqi</au><au>Liang, Tao</au><au>Zhang, Bo</au><au>Du, Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms of Protective Effect of Ramulus Mori Polysaccharides on Renal Injury in High-Fat Diet/Streptozotocin-Induced Diabetic Rats</atitle><jtitle>Cellular Physiology and Biochemistry</jtitle><addtitle>Cell Physiol Biochem</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>37</volume><issue>6</issue><spage>2125</spage><epage>2134</epage><pages>2125-2134</pages><issn>1015-8987</issn><eissn>1421-9778</eissn><abstract>Background: Diabetic nephropathy (DN) is the most important complication of diabetes and the most common cause of end-stage renal disease (ESRD). Aims: A recent study established that the Ramulus mori polysaccharides (RMP) exert antioxidant effects on DN in rats. Methods: The diabetic rats which induced by high-fat diet and streptozotocin injection were orally administered RMP by doses of 250, 500 and 1000 mg/kg daily for 8 weeks. The effects of RMP on hyperglycemia and other biochemical changes were examined in the sera and kidney tissues. Additionally, the pathological and ultrastructural changes and expressions of nuclear-factor kappa B (NF-κB) and transforming growth factor-ß1 (TGF-ß1) were assessed. Results: The results revealed that the serum levels of blood glucose, total cholesterol (TC) and triglycerides (TG) were significantly decreased by RMP. Furthermore, the blood urea nitrogen (BUN), serum creatinine (SCr) and 24-hour urine protein levels in the RMP-medicated rats were lower than those in untreated diabetic rats. Moreover, treatment of the DN rats with RMP normalized all biochemical changes, including the malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels in the serum and kidney tissues. In contrast, the protein expression levels of NF-κB and TGF-ß1, which were enhanced in the kidneys of DN rats, were reduced by RMP. Conclusion: These results suggest that RMP improving the renal function of diabeitc rats possibly via its ameliorating antioxidant activities.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>26599870</pmid><doi>10.1159/000438570</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antioxidant activities Blood Glucose - analysis Cholesterol - blood Complications and side effects Diabetes Mellitus, Experimental - complications Diabetes therapy Diabetic Nephropathies - complications Diabetic Nephropathies - physiopathology Diabetic Nephropathies - prevention & control Diabetic nephropathy Diet, High-Fat Health aspects Kidney - metabolism Kidney - physiopathology Male Mulberry NF-kappa B - metabolism Original Paper Oxidative Stress Patient outcomes Polysaccharides Polysaccharides - pharmacology Ramulus mori polysaccharides Rats Rats, Wistar Renoprotection Streptozocin Streptozocin - administration & dosage Transforming Growth Factor beta1 - metabolism Triglycerides - blood |
| title | Mechanisms of Protective Effect of Ramulus Mori Polysaccharides on Renal Injury in High-Fat Diet/Streptozotocin-Induced Diabetic Rats |
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