Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation
Patients with severe emphysema and no collateral ventilation were assigned to receive endobronchial valves or standard care. Despite valve removal in a third of the patients, an intention-to-treat analysis showed improved function and reduced symptoms in patients who received valves. Bronchoscopic l...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 2015-12, Vol.373 (24), p.2325-2335 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2335 |
|---|---|
| container_issue | 24 |
| container_start_page | 2325 |
| container_title | The New England journal of medicine |
| container_volume | 373 |
| creator | Klooster, Karin ten Hacken, Nick H.T Hartman, Jorine E Kerstjens, Huib A.M van Rikxoort, Eva M Slebos, Dirk-Jan |
| description | Patients with severe emphysema and no collateral ventilation were assigned to receive endobronchial valves or standard care. Despite valve removal in a third of the patients, an intention-to-treat analysis showed improved function and reduced symptoms in patients who received valves.
Bronchoscopic lung-volume reduction with the use of one-way endobronchial valves has emerged as a potential treatment for patients with severe emphysema. This treatment was previously investigated in the randomized, controlled Endobronchial Valve for Emphysema Palliation Trial (VENT),
1
which showed significant but moderate improvements in forced expiratory volume in 1 second (FEV
1
): an increase from baseline of 4.3% (95% confidence interval [CI], 1.4 to 7.2). Post hoc analyses of the VENT data suggested that endobronchial-valve treatment might be more effective in patients who had a complete fissure (as compared with an incomplete fissure) between the lobe that was targeted . . . |
| doi_str_mv | 10.1056/NEJMoa1507807 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1752351384</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1752351384</sourcerecordid><originalsourceid>FETCH-LOGICAL-a413t-25b7ba88c3bcd6212dae89670eb58305ca0289a8ce595742ac5fa7918ae6c8d73</originalsourceid><addsrcrecordid>eNp10MFLwzAUBvAgipvTo1cpiOClmjRJkx5lVJ1MvajX8pqmrKNNZtIq--_N2BQUzCU8-L3Hx4fQKcFXBPP0-il_eLRAOBYSiz00JpzSmDGc7qMxxomMmcjoCB15v8ThEZYdolGSphwHOUbz3FS2dNaoRQNt9Abth_ZRbV2Ud6vF2usOos-mX9ihj2am1661JbhoatsWwrRZ0aZvwtBYc4wOami9Ptn9E_R6m79M7-P5891sejOPgRHaxwkvRQlSKlqqKk1IUoGWWSqwLrmkmCsIuTOQSvOMC5aA4jWIjEjQqZKVoBN0ub27cvZ90L4vusYrHSIZbQdfEMETygmVLNDzP3RpB2dCuqCYECITmAcVb5Vy1nun62Llmg7cuiC42NRc_Ko5-LPd1aHsdPWjv3sN4GILus4XRi-7fw59AcV8g0s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1747779705</pqid></control><display><type>article</type><title>Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>New England Journal of Medicine</source><creator>Klooster, Karin ; ten Hacken, Nick H.T ; Hartman, Jorine E ; Kerstjens, Huib A.M ; van Rikxoort, Eva M ; Slebos, Dirk-Jan</creator><creatorcontrib>Klooster, Karin ; ten Hacken, Nick H.T ; Hartman, Jorine E ; Kerstjens, Huib A.M ; van Rikxoort, Eva M ; Slebos, Dirk-Jan</creatorcontrib><description>Patients with severe emphysema and no collateral ventilation were assigned to receive endobronchial valves or standard care. Despite valve removal in a third of the patients, an intention-to-treat analysis showed improved function and reduced symptoms in patients who received valves.
Bronchoscopic lung-volume reduction with the use of one-way endobronchial valves has emerged as a potential treatment for patients with severe emphysema. This treatment was previously investigated in the randomized, controlled Endobronchial Valve for Emphysema Palliation Trial (VENT),
1
which showed significant but moderate improvements in forced expiratory volume in 1 second (FEV
1
): an increase from baseline of 4.3% (95% confidence interval [CI], 1.4 to 7.2). Post hoc analyses of the VENT data suggested that endobronchial-valve treatment might be more effective in patients who had a complete fissure (as compared with an incomplete fissure) between the lobe that was targeted . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1507807</identifier><identifier>PMID: 26650153</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Aged ; Bronchi ; Emphysema ; Exercise Tolerance ; Female ; Forced Expiratory Volume ; Humans ; Lungs ; Male ; Middle Aged ; Motivation ; Patients ; Pneumothorax ; Prostheses and Implants ; Pulmonary Emphysema - physiopathology ; Pulmonary Emphysema - therapy ; Respiratory function ; Respiratory therapy ; Therapeutic applications ; Ventilation ; Vital Capacity</subject><ispartof>The New England journal of medicine, 2015-12, Vol.373 (24), p.2325-2335</ispartof><rights>Copyright © 2015 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a413t-25b7ba88c3bcd6212dae89670eb58305ca0289a8ce595742ac5fa7918ae6c8d73</citedby><cites>FETCH-LOGICAL-a413t-25b7ba88c3bcd6212dae89670eb58305ca0289a8ce595742ac5fa7918ae6c8d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1507807$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1507807$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26650153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klooster, Karin</creatorcontrib><creatorcontrib>ten Hacken, Nick H.T</creatorcontrib><creatorcontrib>Hartman, Jorine E</creatorcontrib><creatorcontrib>Kerstjens, Huib A.M</creatorcontrib><creatorcontrib>van Rikxoort, Eva M</creatorcontrib><creatorcontrib>Slebos, Dirk-Jan</creatorcontrib><title>Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Patients with severe emphysema and no collateral ventilation were assigned to receive endobronchial valves or standard care. Despite valve removal in a third of the patients, an intention-to-treat analysis showed improved function and reduced symptoms in patients who received valves.
Bronchoscopic lung-volume reduction with the use of one-way endobronchial valves has emerged as a potential treatment for patients with severe emphysema. This treatment was previously investigated in the randomized, controlled Endobronchial Valve for Emphysema Palliation Trial (VENT),
1
which showed significant but moderate improvements in forced expiratory volume in 1 second (FEV
1
): an increase from baseline of 4.3% (95% confidence interval [CI], 1.4 to 7.2). Post hoc analyses of the VENT data suggested that endobronchial-valve treatment might be more effective in patients who had a complete fissure (as compared with an incomplete fissure) between the lobe that was targeted . . .</description><subject>Aged</subject><subject>Bronchi</subject><subject>Emphysema</subject><subject>Exercise Tolerance</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Lungs</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motivation</subject><subject>Patients</subject><subject>Pneumothorax</subject><subject>Prostheses and Implants</subject><subject>Pulmonary Emphysema - physiopathology</subject><subject>Pulmonary Emphysema - therapy</subject><subject>Respiratory function</subject><subject>Respiratory therapy</subject><subject>Therapeutic applications</subject><subject>Ventilation</subject><subject>Vital Capacity</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10MFLwzAUBvAgipvTo1cpiOClmjRJkx5lVJ1MvajX8pqmrKNNZtIq--_N2BQUzCU8-L3Hx4fQKcFXBPP0-il_eLRAOBYSiz00JpzSmDGc7qMxxomMmcjoCB15v8ThEZYdolGSphwHOUbz3FS2dNaoRQNt9Abth_ZRbV2Ud6vF2usOos-mX9ihj2am1661JbhoatsWwrRZ0aZvwtBYc4wOami9Ptn9E_R6m79M7-P5891sejOPgRHaxwkvRQlSKlqqKk1IUoGWWSqwLrmkmCsIuTOQSvOMC5aA4jWIjEjQqZKVoBN0ub27cvZ90L4vusYrHSIZbQdfEMETygmVLNDzP3RpB2dCuqCYECITmAcVb5Vy1nun62Llmg7cuiC42NRc_Ko5-LPd1aHsdPWjv3sN4GILus4XRi-7fw59AcV8g0s</recordid><startdate>20151210</startdate><enddate>20151210</enddate><creator>Klooster, Karin</creator><creator>ten Hacken, Nick H.T</creator><creator>Hartman, Jorine E</creator><creator>Kerstjens, Huib A.M</creator><creator>van Rikxoort, Eva M</creator><creator>Slebos, Dirk-Jan</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20151210</creationdate><title>Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation</title><author>Klooster, Karin ; ten Hacken, Nick H.T ; Hartman, Jorine E ; Kerstjens, Huib A.M ; van Rikxoort, Eva M ; Slebos, Dirk-Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a413t-25b7ba88c3bcd6212dae89670eb58305ca0289a8ce595742ac5fa7918ae6c8d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Bronchi</topic><topic>Emphysema</topic><topic>Exercise Tolerance</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Lungs</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motivation</topic><topic>Patients</topic><topic>Pneumothorax</topic><topic>Prostheses and Implants</topic><topic>Pulmonary Emphysema - physiopathology</topic><topic>Pulmonary Emphysema - therapy</topic><topic>Respiratory function</topic><topic>Respiratory therapy</topic><topic>Therapeutic applications</topic><topic>Ventilation</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klooster, Karin</creatorcontrib><creatorcontrib>ten Hacken, Nick H.T</creatorcontrib><creatorcontrib>Hartman, Jorine E</creatorcontrib><creatorcontrib>Kerstjens, Huib A.M</creatorcontrib><creatorcontrib>van Rikxoort, Eva M</creatorcontrib><creatorcontrib>Slebos, Dirk-Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klooster, Karin</au><au>ten Hacken, Nick H.T</au><au>Hartman, Jorine E</au><au>Kerstjens, Huib A.M</au><au>van Rikxoort, Eva M</au><au>Slebos, Dirk-Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2015-12-10</date><risdate>2015</risdate><volume>373</volume><issue>24</issue><spage>2325</spage><epage>2335</epage><pages>2325-2335</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Patients with severe emphysema and no collateral ventilation were assigned to receive endobronchial valves or standard care. Despite valve removal in a third of the patients, an intention-to-treat analysis showed improved function and reduced symptoms in patients who received valves.
Bronchoscopic lung-volume reduction with the use of one-way endobronchial valves has emerged as a potential treatment for patients with severe emphysema. This treatment was previously investigated in the randomized, controlled Endobronchial Valve for Emphysema Palliation Trial (VENT),
1
which showed significant but moderate improvements in forced expiratory volume in 1 second (FEV
1
): an increase from baseline of 4.3% (95% confidence interval [CI], 1.4 to 7.2). Post hoc analyses of the VENT data suggested that endobronchial-valve treatment might be more effective in patients who had a complete fissure (as compared with an incomplete fissure) between the lobe that was targeted . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>26650153</pmid><doi>10.1056/NEJMoa1507807</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2015-12, Vol.373 (24), p.2325-2335 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1752351384 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Aged Bronchi Emphysema Exercise Tolerance Female Forced Expiratory Volume Humans Lungs Male Middle Aged Motivation Patients Pneumothorax Prostheses and Implants Pulmonary Emphysema - physiopathology Pulmonary Emphysema - therapy Respiratory function Respiratory therapy Therapeutic applications Ventilation Vital Capacity |
| title | Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T23%3A37%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endobronchial%20Valves%20for%20Emphysema%20without%20Interlobar%20Collateral%20Ventilation&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Klooster,%20Karin&rft.date=2015-12-10&rft.volume=373&rft.issue=24&rft.spage=2325&rft.epage=2335&rft.pages=2325-2335&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMoa1507807&rft_dat=%3Cproquest_cross%3E1752351384%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1747779705&rft_id=info:pmid/26650153&rfr_iscdi=true |