Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method
Purpose This study is to design a sustained release solid dispersion using swellable polymer by melting method. Methods Polyethylene glycol 6000 (PEG 6000) and hydroxypropyl methylcellulose 4000 (HPMC 4000) were used in solid dispersion for not only enhancing drug dissolution rate but also sustainin...
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| Veröffentlicht in: | Pharmaceutical research 2016-01, Vol.33 (1), p.102-109 |
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| creator | Nguyen, Tuong Ngoc-Gia Tran, Phuong Ha-Lien Van Vo, Toi Duan, Wei Truong-Dinh Tran, Thao |
| description | Purpose
This study is to design a sustained release solid dispersion using swellable polymer by melting method.
Methods
Polyethylene glycol 6000 (PEG 6000) and hydroxypropyl methylcellulose 4000 (HPMC 4000) were used in solid dispersion for not only enhancing drug dissolution rate but also sustaining drug release. HPMC 4000 is a common swellable polymer in matrix sustained release dosage form, but could not be used in preparation of solid dispersion by melting method. However, the current study utilized the swelling capability of HPMC 4000 accompanied by the common carrier PEG 6000 in solid dispersion to accomplish the goal.
Results
While PEG 6000 acted as a releasing stimulant carrier and provided an environment to facilitate the swelling of HPMC 4000, this swellable polymer could act as a rate-controlling agent. This greatly assisted the dissolution enhancement by changing the crystalline structure of drug to more amorphous form and creating a molecular interaction.
Conclusions
These results suggested that this useful technique can be applied in designing a sustained release solid dispersion with many advantages. |
| doi_str_mv | 10.1007/s11095-015-1767-2 |
| format | Article |
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This study is to design a sustained release solid dispersion using swellable polymer by melting method.
Methods
Polyethylene glycol 6000 (PEG 6000) and hydroxypropyl methylcellulose 4000 (HPMC 4000) were used in solid dispersion for not only enhancing drug dissolution rate but also sustaining drug release. HPMC 4000 is a common swellable polymer in matrix sustained release dosage form, but could not be used in preparation of solid dispersion by melting method. However, the current study utilized the swelling capability of HPMC 4000 accompanied by the common carrier PEG 6000 in solid dispersion to accomplish the goal.
Results
While PEG 6000 acted as a releasing stimulant carrier and provided an environment to facilitate the swelling of HPMC 4000, this swellable polymer could act as a rate-controlling agent. This greatly assisted the dissolution enhancement by changing the crystalline structure of drug to more amorphous form and creating a molecular interaction.
Conclusions
These results suggested that this useful technique can be applied in designing a sustained release solid dispersion with many advantages.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1007/s11095-015-1767-2</identifier><identifier>PMID: 26264511</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Chemistry, Pharmaceutical ; Communications industry ; Delayed-Action Preparations ; Dispersion ; Drug delivery systems ; Drug Design ; Hypromellose Derivatives - chemistry ; Medical Law ; Methods ; Methylcellulose ; Patient compliance ; Pharmaceutical sciences ; Pharmacology/Toxicology ; Pharmacy ; Polyethylene Glycols - chemistry ; Polymer industry ; Polymers ; Research Paper ; Solubility ; Tablets ; Telecommunications services industry ; X-Ray Diffraction</subject><ispartof>Pharmaceutical research, 2016-01, Vol.33 (1), p.102-109</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-fd6bf58759efd10e49a7c4ce3ad3ad9b97c3986a6051b3123f51400b4b3ae5703</citedby><cites>FETCH-LOGICAL-c509t-fd6bf58759efd10e49a7c4ce3ad3ad9b97c3986a6051b3123f51400b4b3ae5703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11095-015-1767-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11095-015-1767-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26264511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, Tuong Ngoc-Gia</creatorcontrib><creatorcontrib>Tran, Phuong Ha-Lien</creatorcontrib><creatorcontrib>Van Vo, Toi</creatorcontrib><creatorcontrib>Duan, Wei</creatorcontrib><creatorcontrib>Truong-Dinh Tran, Thao</creatorcontrib><title>Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><addtitle>Pharm Res</addtitle><description>Purpose
This study is to design a sustained release solid dispersion using swellable polymer by melting method.
Methods
Polyethylene glycol 6000 (PEG 6000) and hydroxypropyl methylcellulose 4000 (HPMC 4000) were used in solid dispersion for not only enhancing drug dissolution rate but also sustaining drug release. HPMC 4000 is a common swellable polymer in matrix sustained release dosage form, but could not be used in preparation of solid dispersion by melting method. However, the current study utilized the swelling capability of HPMC 4000 accompanied by the common carrier PEG 6000 in solid dispersion to accomplish the goal.
Results
While PEG 6000 acted as a releasing stimulant carrier and provided an environment to facilitate the swelling of HPMC 4000, this swellable polymer could act as a rate-controlling agent. This greatly assisted the dissolution enhancement by changing the crystalline structure of drug to more amorphous form and creating a molecular interaction.
Conclusions
These results suggested that this useful technique can be applied in designing a sustained release solid dispersion with many advantages.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Chemistry, Pharmaceutical</subject><subject>Communications industry</subject><subject>Delayed-Action Preparations</subject><subject>Dispersion</subject><subject>Drug delivery systems</subject><subject>Drug Design</subject><subject>Hypromellose Derivatives - chemistry</subject><subject>Medical Law</subject><subject>Methods</subject><subject>Methylcellulose</subject><subject>Patient compliance</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymer industry</subject><subject>Polymers</subject><subject>Research Paper</subject><subject>Solubility</subject><subject>Tablets</subject><subject>Telecommunications services industry</subject><subject>X-Ray Diffraction</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kV1rFDEYhYModq3-AG8k4I03U_Nm8rG5LK1f0KK4FryRkJl5Z03JTLbJjLL_3oxbP1ESCOR9zuEkh5DHwE6AMf08AzAjKwayAq10xe-QFUhdV4aJj3fJimkuqrUWcEQe5HzNGFuDEffJEVdcCQmwIp_O8QuGuBtwnGjsqaObOU_Oj9jR9xjQZaSbGHxHz33eYco-jvQq-3FLN18xBNcEpO9i2A-YaLOnlximZXiJ0-fYPST3ehcyPro9j8nVyxcfzl5XF29fvTk7vahaycxU9Z1qernW0mDfAUNhnG5Fi7XryjaN0W1t1sopJqGpgde9BMFYI5raodSsPibPDr67FG9mzJMdfG6XeCPGOVvQEoyRqhYFffoXeh3nNJZ036lac8nVL2rrAlo_9nFKrl1M7Wn5VA5cqYU6-QdVVoeDb-OIvS_3fwjgIGhTzDlhb3fJDy7tLTC7VGoPldpSqV0qtbxontwGnpsBu5-KHx0WgB-AXEbjFtNvL_qv6zfKx6mF</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Nguyen, Tuong Ngoc-Gia</creator><creator>Tran, Phuong Ha-Lien</creator><creator>Van Vo, Toi</creator><creator>Duan, Wei</creator><creator>Truong-Dinh Tran, Thao</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20160101</creationdate><title>Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method</title><author>Nguyen, Tuong Ngoc-Gia ; Tran, Phuong Ha-Lien ; Van Vo, Toi ; Duan, Wei ; Truong-Dinh Tran, Thao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-fd6bf58759efd10e49a7c4ce3ad3ad9b97c3986a6051b3123f51400b4b3ae5703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Chemistry, Pharmaceutical</topic><topic>Communications industry</topic><topic>Delayed-Action Preparations</topic><topic>Dispersion</topic><topic>Drug delivery systems</topic><topic>Drug Design</topic><topic>Hypromellose Derivatives - chemistry</topic><topic>Medical Law</topic><topic>Methods</topic><topic>Methylcellulose</topic><topic>Patient compliance</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polymer industry</topic><topic>Polymers</topic><topic>Research Paper</topic><topic>Solubility</topic><topic>Tablets</topic><topic>Telecommunications services industry</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Tuong Ngoc-Gia</creatorcontrib><creatorcontrib>Tran, Phuong Ha-Lien</creatorcontrib><creatorcontrib>Van Vo, Toi</creatorcontrib><creatorcontrib>Duan, Wei</creatorcontrib><creatorcontrib>Truong-Dinh Tran, Thao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Tuong Ngoc-Gia</au><au>Tran, Phuong Ha-Lien</au><au>Van Vo, Toi</au><au>Duan, Wei</au><au>Truong-Dinh Tran, Thao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method</atitle><jtitle>Pharmaceutical research</jtitle><stitle>Pharm Res</stitle><addtitle>Pharm Res</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>33</volume><issue>1</issue><spage>102</spage><epage>109</epage><pages>102-109</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><abstract>Purpose
This study is to design a sustained release solid dispersion using swellable polymer by melting method.
Methods
Polyethylene glycol 6000 (PEG 6000) and hydroxypropyl methylcellulose 4000 (HPMC 4000) were used in solid dispersion for not only enhancing drug dissolution rate but also sustaining drug release. HPMC 4000 is a common swellable polymer in matrix sustained release dosage form, but could not be used in preparation of solid dispersion by melting method. However, the current study utilized the swelling capability of HPMC 4000 accompanied by the common carrier PEG 6000 in solid dispersion to accomplish the goal.
Results
While PEG 6000 acted as a releasing stimulant carrier and provided an environment to facilitate the swelling of HPMC 4000, this swellable polymer could act as a rate-controlling agent. This greatly assisted the dissolution enhancement by changing the crystalline structure of drug to more amorphous form and creating a molecular interaction.
Conclusions
These results suggested that this useful technique can be applied in designing a sustained release solid dispersion with many advantages.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26264511</pmid><doi>10.1007/s11095-015-1767-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | Pharmaceutical research, 2016-01, Vol.33 (1), p.102-109 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemistry, Pharmaceutical Communications industry Delayed-Action Preparations Dispersion Drug delivery systems Drug Design Hypromellose Derivatives - chemistry Medical Law Methods Methylcellulose Patient compliance Pharmaceutical sciences Pharmacology/Toxicology Pharmacy Polyethylene Glycols - chemistry Polymer industry Polymers Research Paper Solubility Tablets Telecommunications services industry X-Ray Diffraction |
| title | Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method |
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