Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light

Trans diiodido platinum(II) complexes bearing the same as well as different aliphatic amines (mixed-amines) have interesting biological activity; cytotoxicity and interactions with some important biological models have already been demonstrated. Herein we described the interaction of such compounds with ct-DNA, supercoiled and linearized plasmid DNA and 5-GMP. Interestingly, UV irradiation of these compounds results in an increase in reactivity towards DNA and 5-GMP in such model systems. Additionally, the cytotoxicity of the trans-Pt(II) complexes towards human cancer cells is noticeably increased when treatment is combined for 90min with UVA-irradiation. With this work we provide evidence that trans diiodido compounds can be activated by UV-light over relatively short treatment times. Trans diiodido platinum(II) complexes bearing the same as well as different aliphatic amines (mixed-amines) are examined in detail: cytotoxicity and interactions with some important biological models. Interestingly, UV irradiation of these compounds results in an increase in reactivity towards DNA in such model systems. Additionally, the cytotoxicity is noticeably increased by UV-light over short treatment times. [Display omitted] •Trans diiodido platinum(II) complexes biological activity; cytotoxicity under irradiation•The platinum complexes interactions are studied with some important biological models ct-DNA, plasmid DNA and 5-GMP•UV irradiation of these compounds results in an increase in reactivity towards DNA and 5-GMP in such model systems.•trans-Pt(II) complexes cytotoxicity towards human cancer cells increases when treatment is combined for 90min with UVA-irradiation.