MMP-2 serum concentrations predict mortality in hemodialysis patients: a 5-year cohort study
We evaluated the ability of matrix metalloproteinase (MMP)-2, MMP-9, myeloperoxidase, osteopontin and stromal cell-derived factor 1 to predict mortality in hemodialysis (HD) patients. One hundred forty HD patients were enrolled and followed from December 2007 until December 2012. At the end of this...
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| Veröffentlicht in: | Clinica chimica acta 2016-01, Vol.452, p.161-166 |
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| container_title | Clinica chimica acta |
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| creator | Hsiao, Kuang-Chih Tsai, Jen-Pi Yang, Shun-Fa Lee, Wen-Chin Huang, Jong-Yu Chang, Shun-Chi Hso, Chun-Shuo Chang, Horng-Rong |
| description | We evaluated the ability of matrix metalloproteinase (MMP)-2, MMP-9, myeloperoxidase, osteopontin and stromal cell-derived factor 1 to predict mortality in hemodialysis (HD) patients.
One hundred forty HD patients were enrolled and followed from December 2007 until December 2012. At the end of this 5-year period, data were compared between the patients who were alive and those who had died.
The patients who alive were younger (56 vs. 63y), with lower frequency of diabetes mellitus (34.34% vs. 58.53%), higher concentrations of albumin (4.13 vs. 3.91mg/dl) and lower concentrations of MMP-2 (430.76 vs. 521.59ng/ml). Multivariate analysis showed that age (HR=1.03, p=0.02), diabetes mellitus (HR=2.395, p=0.012), albumin (HR=0.475, p=0.047) and MMP-2 (HR=1.003, p=0.005) were independent factors predicting mortality in HD patients. Receiver operating characteristic curve analysis showed that albumin (AUC=0.628, p=0.027) and MMP-2 (AUC=0.643, p=0.004) had a similar ability (p=0.76) to predict survival of HD patients.
Compared with albumin, serum MMP-2 is a non-inferior prognostic marker for predicting the survival of HD patients.
•A retrospective cohort study investigated the role of MMP-2 in predicting mortality in hemodialysis patients.•Albumin is a powerful mortality predictor in hemodialysis patients.•Our result showed MMP-2 is independently associated with mortality in hemodialysis patients.•Compared with albumin, MMP-2 is a non-inferior prognostic marker for predicting the survival of HD patients. |
| doi_str_mv | 10.1016/j.cca.2015.11.019 |
| format | Article |
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One hundred forty HD patients were enrolled and followed from December 2007 until December 2012. At the end of this 5-year period, data were compared between the patients who were alive and those who had died.
The patients who alive were younger (56 vs. 63y), with lower frequency of diabetes mellitus (34.34% vs. 58.53%), higher concentrations of albumin (4.13 vs. 3.91mg/dl) and lower concentrations of MMP-2 (430.76 vs. 521.59ng/ml). Multivariate analysis showed that age (HR=1.03, p=0.02), diabetes mellitus (HR=2.395, p=0.012), albumin (HR=0.475, p=0.047) and MMP-2 (HR=1.003, p=0.005) were independent factors predicting mortality in HD patients. Receiver operating characteristic curve analysis showed that albumin (AUC=0.628, p=0.027) and MMP-2 (AUC=0.643, p=0.004) had a similar ability (p=0.76) to predict survival of HD patients.
Compared with albumin, serum MMP-2 is a non-inferior prognostic marker for predicting the survival of HD patients.
•A retrospective cohort study investigated the role of MMP-2 in predicting mortality in hemodialysis patients.•Albumin is a powerful mortality predictor in hemodialysis patients.•Our result showed MMP-2 is independently associated with mortality in hemodialysis patients.•Compared with albumin, MMP-2 is a non-inferior prognostic marker for predicting the survival of HD patients.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2015.11.019</identifier><identifier>PMID: 26612771</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Albumin ; Albumins - analysis ; Biomarkers - blood ; Cohort Studies ; Hemodialysis ; Humans ; Kaplan-Meier Estimate ; Matrix metalloproteinase ; Matrix Metalloproteinase 2 - blood ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Renal Dialysis - mortality ; ROC Curve ; Software ; Survival</subject><ispartof>Clinica chimica acta, 2016-01, Vol.452, p.161-166</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-107065640e09acf19f2ca2bea2b859d4b4127b23cc19d2e248da9f139e965eb23</citedby><cites>FETCH-LOGICAL-c353t-107065640e09acf19f2ca2bea2b859d4b4127b23cc19d2e248da9f139e965eb23</cites><orcidid>0000-0002-6097-4056</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009898115300565$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26612771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsiao, Kuang-Chih</creatorcontrib><creatorcontrib>Tsai, Jen-Pi</creatorcontrib><creatorcontrib>Yang, Shun-Fa</creatorcontrib><creatorcontrib>Lee, Wen-Chin</creatorcontrib><creatorcontrib>Huang, Jong-Yu</creatorcontrib><creatorcontrib>Chang, Shun-Chi</creatorcontrib><creatorcontrib>Hso, Chun-Shuo</creatorcontrib><creatorcontrib>Chang, Horng-Rong</creatorcontrib><title>MMP-2 serum concentrations predict mortality in hemodialysis patients: a 5-year cohort study</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>We evaluated the ability of matrix metalloproteinase (MMP)-2, MMP-9, myeloperoxidase, osteopontin and stromal cell-derived factor 1 to predict mortality in hemodialysis (HD) patients.
One hundred forty HD patients were enrolled and followed from December 2007 until December 2012. At the end of this 5-year period, data were compared between the patients who were alive and those who had died.
The patients who alive were younger (56 vs. 63y), with lower frequency of diabetes mellitus (34.34% vs. 58.53%), higher concentrations of albumin (4.13 vs. 3.91mg/dl) and lower concentrations of MMP-2 (430.76 vs. 521.59ng/ml). Multivariate analysis showed that age (HR=1.03, p=0.02), diabetes mellitus (HR=2.395, p=0.012), albumin (HR=0.475, p=0.047) and MMP-2 (HR=1.003, p=0.005) were independent factors predicting mortality in HD patients. Receiver operating characteristic curve analysis showed that albumin (AUC=0.628, p=0.027) and MMP-2 (AUC=0.643, p=0.004) had a similar ability (p=0.76) to predict survival of HD patients.
Compared with albumin, serum MMP-2 is a non-inferior prognostic marker for predicting the survival of HD patients.
•A retrospective cohort study investigated the role of MMP-2 in predicting mortality in hemodialysis patients.•Albumin is a powerful mortality predictor in hemodialysis patients.•Our result showed MMP-2 is independently associated with mortality in hemodialysis patients.•Compared with albumin, MMP-2 is a non-inferior prognostic marker for predicting the survival of HD patients.</description><subject>Albumin</subject><subject>Albumins - analysis</subject><subject>Biomarkers - blood</subject><subject>Cohort Studies</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 2 - blood</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Predictive Value of Tests</subject><subject>Renal Dialysis - mortality</subject><subject>ROC Curve</subject><subject>Software</subject><subject>Survival</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotlYfwI1k6WbGnMw1upLiDVp0oTshpJkzNGUuNckI8_amtLp0EQ7hfP9P8hFyCSwGBvnNJtZaxZxBFgPEDMQRmUJZJFGSCn5MpowxEZWihAk5c24TrinL4ZRMeJ4DLwqYks_l8i3i1KEdWqr7TmPnrfKm7xzdWqyM9rTtrVeN8SM1HV1j21dGNaMzgQhkCLhbqmgWjahs6FgHnDo_VOM5OalV4_DiMGfk4_Hhff4cLV6fXub3i0gnWeIjYAXLszxlyITSNYiaa8VXGE6ZiSpdpeGxK55oDaLiyNOyUqKGRKDIMwyLGbne925t_zWg87I1TmPTqA77wUkoMhCCJWKHwh7VtnfOYi231rTKjhKY3EmVGxmkyp1UCSCD1JC5OtQPqxarv8SvxQDc7QEMn_w2aKXTwYsO-ixqL6ve_FP_A5Jih3k</recordid><startdate>20160115</startdate><enddate>20160115</enddate><creator>Hsiao, Kuang-Chih</creator><creator>Tsai, Jen-Pi</creator><creator>Yang, Shun-Fa</creator><creator>Lee, Wen-Chin</creator><creator>Huang, Jong-Yu</creator><creator>Chang, Shun-Chi</creator><creator>Hso, Chun-Shuo</creator><creator>Chang, Horng-Rong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6097-4056</orcidid></search><sort><creationdate>20160115</creationdate><title>MMP-2 serum concentrations predict mortality in hemodialysis patients: a 5-year cohort study</title><author>Hsiao, Kuang-Chih ; Tsai, Jen-Pi ; Yang, Shun-Fa ; Lee, Wen-Chin ; Huang, Jong-Yu ; Chang, Shun-Chi ; Hso, Chun-Shuo ; Chang, Horng-Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-107065640e09acf19f2ca2bea2b859d4b4127b23cc19d2e248da9f139e965eb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Albumin</topic><topic>Albumins - analysis</topic><topic>Biomarkers - blood</topic><topic>Cohort Studies</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 2 - blood</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Predictive Value of Tests</topic><topic>Renal Dialysis - mortality</topic><topic>ROC Curve</topic><topic>Software</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsiao, Kuang-Chih</creatorcontrib><creatorcontrib>Tsai, Jen-Pi</creatorcontrib><creatorcontrib>Yang, Shun-Fa</creatorcontrib><creatorcontrib>Lee, Wen-Chin</creatorcontrib><creatorcontrib>Huang, Jong-Yu</creatorcontrib><creatorcontrib>Chang, Shun-Chi</creatorcontrib><creatorcontrib>Hso, Chun-Shuo</creatorcontrib><creatorcontrib>Chang, Horng-Rong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsiao, Kuang-Chih</au><au>Tsai, Jen-Pi</au><au>Yang, Shun-Fa</au><au>Lee, Wen-Chin</au><au>Huang, Jong-Yu</au><au>Chang, Shun-Chi</au><au>Hso, Chun-Shuo</au><au>Chang, Horng-Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MMP-2 serum concentrations predict mortality in hemodialysis patients: a 5-year cohort study</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2016-01-15</date><risdate>2016</risdate><volume>452</volume><spage>161</spage><epage>166</epage><pages>161-166</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>We evaluated the ability of matrix metalloproteinase (MMP)-2, MMP-9, myeloperoxidase, osteopontin and stromal cell-derived factor 1 to predict mortality in hemodialysis (HD) patients.
One hundred forty HD patients were enrolled and followed from December 2007 until December 2012. At the end of this 5-year period, data were compared between the patients who were alive and those who had died.
The patients who alive were younger (56 vs. 63y), with lower frequency of diabetes mellitus (34.34% vs. 58.53%), higher concentrations of albumin (4.13 vs. 3.91mg/dl) and lower concentrations of MMP-2 (430.76 vs. 521.59ng/ml). Multivariate analysis showed that age (HR=1.03, p=0.02), diabetes mellitus (HR=2.395, p=0.012), albumin (HR=0.475, p=0.047) and MMP-2 (HR=1.003, p=0.005) were independent factors predicting mortality in HD patients. Receiver operating characteristic curve analysis showed that albumin (AUC=0.628, p=0.027) and MMP-2 (AUC=0.643, p=0.004) had a similar ability (p=0.76) to predict survival of HD patients.
Compared with albumin, serum MMP-2 is a non-inferior prognostic marker for predicting the survival of HD patients.
•A retrospective cohort study investigated the role of MMP-2 in predicting mortality in hemodialysis patients.•Albumin is a powerful mortality predictor in hemodialysis patients.•Our result showed MMP-2 is independently associated with mortality in hemodialysis patients.•Compared with albumin, MMP-2 is a non-inferior prognostic marker for predicting the survival of HD patients.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26612771</pmid><doi>10.1016/j.cca.2015.11.019</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6097-4056</orcidid></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Albumin Albumins - analysis Biomarkers - blood Cohort Studies Hemodialysis Humans Kaplan-Meier Estimate Matrix metalloproteinase Matrix Metalloproteinase 2 - blood Middle Aged Multivariate Analysis Predictive Value of Tests Renal Dialysis - mortality ROC Curve Software Survival |
| title | MMP-2 serum concentrations predict mortality in hemodialysis patients: a 5-year cohort study |
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