Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene

5-Aminolevulinate synthase (ALAS) catalyzes the first step of the heme biosynthetic pathway in mammalian cells. Separate genes encode the two isoforms: ubiquitously expressed ALAS (ALAS1) and erythroid-specific ALAS (ALAS2). Transcription of the ALAS2 gene is only activated during erythroid cell dif...

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Veröffentlicht in:	Gene 2000-04, Vol.247 (1), p.153-166
Hauptverfasser:	Kramer, Marianne F, Gunaratne, Prabha, Ferreira, Gloria C
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells 5-Aminolevulinate Synthetase - genetics ALAS2 gene Animals Base Sequence Binding Sites - genetics Conserved Sequence dimethylsulfoxide DNA - chemistry DNA - genetics DNA - metabolism Erythrocytes - enzymology Gene Expression Regulation, Enzymologic HeLa Cells Heme biosynthesis Humans K562 Cells Luciferases - genetics Luciferases - metabolism Mice Molecular Sequence Data Mutagenesis, Site-Directed Mutation Promoter Promoter Regions, Genetic - genetics Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Regulatory sequences Regulatory Sequences, Nucleic Acid Sequence Analysis, DNA Trans-Activators - metabolism Transcription, Genetic Transcriptional factors Tumor Cells, Cultured
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