Scopolamine Augments the Efficacy of Physostigmine Against Soman Poisoning in Guinea Pigs
The efficacy of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic receptor antagonist scopolamine (SCO) (0.018 mg/kg/h) in counteracting soman-induced lethality and incapacitation were determined in guinea pigs. This...
Gespeichert in:
| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2000, Vol.65 (1), p.175-182 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 182 |
|---|---|
| container_issue | 1 |
| container_start_page | 175 |
| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 65 |
| creator | Philippens, Ingrid H.C.H.M Melchers, Bert P.C Olivier, Berend Bruijnzeel, Piet L.B |
| description | The efficacy of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic receptor antagonist scopolamine (SCO) (0.018 mg/kg/h) in counteracting soman-induced lethality and incapacitation were determined in guinea pigs. This was tested in animals that either received atropine sulphate (AS, 17.4 mg/kg IM) or no postintoxication therapy. Behavioral and neurophysiological readout systems were used to measure postintoxication incapacitation. Only the pretreatment with PHY alone did not offer any protection against 2× LD
50 soman intoxication. Animals that received the complete treatment (PHY + SCO + AS) did not show any abberations in the performance of learned behavior. The use of AS after soman intoxication resulted in an increase of the startle response, whereas the addition of SCO to the pretreatment led to a more persistent duration of the effect in time. In case one has to rely completely on the pretreatment, the addition of SCO to PHY is life-saving. However, some postintoxication incapacitation is still present. Therefore, the pretreatment regime may perhaps further be improved by the addition of a nicotinic antagonist. |
| doi_str_mv | 10.1016/S0091-3057(99)00171-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17519651</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091305799001719</els_id><sourcerecordid>17519651</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-fbb5c1336a24e99895e3fbf3f6ca9299834adcda820c1299d8e15629db9349cd3</originalsourceid><addsrcrecordid>eNqF0E1rFDEYwPEgil2rH0HJQUQPU_NM5i2nUkqtQqELqwdPIZN5Mo3MJOs8M8J-e9POor31FBJ-efsz9hbEGQioPu-EUJBJUdYflfokBNSQqWdsA00tsxLq-jnb_CMn7BXRLyFEkVf1S3YCopJNVcKG_dzZuI-DGX1AfrH0I4aZ-HyH_Mo5b4098Oj49u5AkWbfr6w3PtDMd3E0gW-jpxh86LkP_HpJwPCt7-k1e-HMQPjmOJ6yH1-uvl9-zW5ur79dXtxktshhzlzblhakrExeoFKNKlG61klXWaPytCAL09nONLmwkOZdg1BWuepaJQtlO3nKPqzn7qf4e0Ga9ejJ4jCYgHEhDXUJKv01wXKFdopEEzq9n_xopoMGoe-b6oem-j6YVko_NNUq7Xt3vGBpR-we7VojJvD-CAxZM7jJBOvpv8vzugCR2PnKMNX443HSZD0Gi52f0M66i_6Jl_wFtu2TMg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17519651</pqid></control><display><type>article</type><title>Scopolamine Augments the Efficacy of Physostigmine Against Soman Poisoning in Guinea Pigs</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Philippens, Ingrid H.C.H.M ; Melchers, Bert P.C ; Olivier, Berend ; Bruijnzeel, Piet L.B</creator><creatorcontrib>Philippens, Ingrid H.C.H.M ; Melchers, Bert P.C ; Olivier, Berend ; Bruijnzeel, Piet L.B</creatorcontrib><description>The efficacy of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic receptor antagonist scopolamine (SCO) (0.018 mg/kg/h) in counteracting soman-induced lethality and incapacitation were determined in guinea pigs. This was tested in animals that either received atropine sulphate (AS, 17.4 mg/kg IM) or no postintoxication therapy. Behavioral and neurophysiological readout systems were used to measure postintoxication incapacitation. Only the pretreatment with PHY alone did not offer any protection against 2× LD
50 soman intoxication. Animals that received the complete treatment (PHY + SCO + AS) did not show any abberations in the performance of learned behavior. The use of AS after soman intoxication resulted in an increase of the startle response, whereas the addition of SCO to the pretreatment led to a more persistent duration of the effect in time. In case one has to rely completely on the pretreatment, the addition of SCO to PHY is life-saving. However, some postintoxication incapacitation is still present. Therefore, the pretreatment regime may perhaps further be improved by the addition of a nicotinic antagonist.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(99)00171-9</identifier><identifier>PMID: 10638651</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Behavior ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Cholinesterase ; Cholinesterase Inhibitors - therapeutic use ; Drug Synergism ; Electroencephalography - drug effects ; Guinea pig ; Guinea Pigs ; Male ; Medical sciences ; Muscarinic Antagonists - therapeutic use ; Physostigmine ; Physostigmine - therapeutic use ; Physostigmine - toxicity ; Pretreatment ; Reflex, Startle - drug effects ; Scopolamine ; Scopolamine - therapeutic use ; Scopolamine - toxicity ; Soman ; Soman - poisoning ; Subchronic ; Toxicology ; Various organic compounds</subject><ispartof>Pharmacology, biochemistry and behavior, 2000, Vol.65 (1), p.175-182</ispartof><rights>2000 Elsevier Science Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-fbb5c1336a24e99895e3fbf3f6ca9299834adcda820c1299d8e15629db9349cd3</citedby><cites>FETCH-LOGICAL-c421t-fbb5c1336a24e99895e3fbf3f6ca9299834adcda820c1299d8e15629db9349cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091305799001719$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1227410$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10638651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Philippens, Ingrid H.C.H.M</creatorcontrib><creatorcontrib>Melchers, Bert P.C</creatorcontrib><creatorcontrib>Olivier, Berend</creatorcontrib><creatorcontrib>Bruijnzeel, Piet L.B</creatorcontrib><title>Scopolamine Augments the Efficacy of Physostigmine Against Soman Poisoning in Guinea Pigs</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The efficacy of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic receptor antagonist scopolamine (SCO) (0.018 mg/kg/h) in counteracting soman-induced lethality and incapacitation were determined in guinea pigs. This was tested in animals that either received atropine sulphate (AS, 17.4 mg/kg IM) or no postintoxication therapy. Behavioral and neurophysiological readout systems were used to measure postintoxication incapacitation. Only the pretreatment with PHY alone did not offer any protection against 2× LD
50 soman intoxication. Animals that received the complete treatment (PHY + SCO + AS) did not show any abberations in the performance of learned behavior. The use of AS after soman intoxication resulted in an increase of the startle response, whereas the addition of SCO to the pretreatment led to a more persistent duration of the effect in time. In case one has to rely completely on the pretreatment, the addition of SCO to PHY is life-saving. However, some postintoxication incapacitation is still present. Therefore, the pretreatment regime may perhaps further be improved by the addition of a nicotinic antagonist.</description><subject>Animals</subject><subject>Behavior</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cholinesterase</subject><subject>Cholinesterase Inhibitors - therapeutic use</subject><subject>Drug Synergism</subject><subject>Electroencephalography - drug effects</subject><subject>Guinea pig</subject><subject>Guinea Pigs</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscarinic Antagonists - therapeutic use</subject><subject>Physostigmine</subject><subject>Physostigmine - therapeutic use</subject><subject>Physostigmine - toxicity</subject><subject>Pretreatment</subject><subject>Reflex, Startle - drug effects</subject><subject>Scopolamine</subject><subject>Scopolamine - therapeutic use</subject><subject>Scopolamine - toxicity</subject><subject>Soman</subject><subject>Soman - poisoning</subject><subject>Subchronic</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1rFDEYwPEgil2rH0HJQUQPU_NM5i2nUkqtQqELqwdPIZN5Mo3MJOs8M8J-e9POor31FBJ-efsz9hbEGQioPu-EUJBJUdYflfokBNSQqWdsA00tsxLq-jnb_CMn7BXRLyFEkVf1S3YCopJNVcKG_dzZuI-DGX1AfrH0I4aZ-HyH_Mo5b4098Oj49u5AkWbfr6w3PtDMd3E0gW-jpxh86LkP_HpJwPCt7-k1e-HMQPjmOJ6yH1-uvl9-zW5ur79dXtxktshhzlzblhakrExeoFKNKlG61klXWaPytCAL09nONLmwkOZdg1BWuepaJQtlO3nKPqzn7qf4e0Ga9ejJ4jCYgHEhDXUJKv01wXKFdopEEzq9n_xopoMGoe-b6oem-j6YVko_NNUq7Xt3vGBpR-we7VojJvD-CAxZM7jJBOvpv8vzugCR2PnKMNX443HSZD0Gi52f0M66i_6Jl_wFtu2TMg</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Philippens, Ingrid H.C.H.M</creator><creator>Melchers, Bert P.C</creator><creator>Olivier, Berend</creator><creator>Bruijnzeel, Piet L.B</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2000</creationdate><title>Scopolamine Augments the Efficacy of Physostigmine Against Soman Poisoning in Guinea Pigs</title><author>Philippens, Ingrid H.C.H.M ; Melchers, Bert P.C ; Olivier, Berend ; Bruijnzeel, Piet L.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-fbb5c1336a24e99895e3fbf3f6ca9299834adcda820c1299d8e15629db9349cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Behavior</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Cholinesterase</topic><topic>Cholinesterase Inhibitors - therapeutic use</topic><topic>Drug Synergism</topic><topic>Electroencephalography - drug effects</topic><topic>Guinea pig</topic><topic>Guinea Pigs</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscarinic Antagonists - therapeutic use</topic><topic>Physostigmine</topic><topic>Physostigmine - therapeutic use</topic><topic>Physostigmine - toxicity</topic><topic>Pretreatment</topic><topic>Reflex, Startle - drug effects</topic><topic>Scopolamine</topic><topic>Scopolamine - therapeutic use</topic><topic>Scopolamine - toxicity</topic><topic>Soman</topic><topic>Soman - poisoning</topic><topic>Subchronic</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Philippens, Ingrid H.C.H.M</creatorcontrib><creatorcontrib>Melchers, Bert P.C</creatorcontrib><creatorcontrib>Olivier, Berend</creatorcontrib><creatorcontrib>Bruijnzeel, Piet L.B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Philippens, Ingrid H.C.H.M</au><au>Melchers, Bert P.C</au><au>Olivier, Berend</au><au>Bruijnzeel, Piet L.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scopolamine Augments the Efficacy of Physostigmine Against Soman Poisoning in Guinea Pigs</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2000</date><risdate>2000</risdate><volume>65</volume><issue>1</issue><spage>175</spage><epage>182</epage><pages>175-182</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The efficacy of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic receptor antagonist scopolamine (SCO) (0.018 mg/kg/h) in counteracting soman-induced lethality and incapacitation were determined in guinea pigs. This was tested in animals that either received atropine sulphate (AS, 17.4 mg/kg IM) or no postintoxication therapy. Behavioral and neurophysiological readout systems were used to measure postintoxication incapacitation. Only the pretreatment with PHY alone did not offer any protection against 2× LD
50 soman intoxication. Animals that received the complete treatment (PHY + SCO + AS) did not show any abberations in the performance of learned behavior. The use of AS after soman intoxication resulted in an increase of the startle response, whereas the addition of SCO to the pretreatment led to a more persistent duration of the effect in time. In case one has to rely completely on the pretreatment, the addition of SCO to PHY is life-saving. However, some postintoxication incapacitation is still present. Therefore, the pretreatment regime may perhaps further be improved by the addition of a nicotinic antagonist.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10638651</pmid><doi>10.1016/S0091-3057(99)00171-9</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 2000, Vol.65 (1), p.175-182 |
| issn | 0091-3057 1873-5177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17519651 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Behavior Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cholinesterase Cholinesterase Inhibitors - therapeutic use Drug Synergism Electroencephalography - drug effects Guinea pig Guinea Pigs Male Medical sciences Muscarinic Antagonists - therapeutic use Physostigmine Physostigmine - therapeutic use Physostigmine - toxicity Pretreatment Reflex, Startle - drug effects Scopolamine Scopolamine - therapeutic use Scopolamine - toxicity Soman Soman - poisoning Subchronic Toxicology Various organic compounds |
| title | Scopolamine Augments the Efficacy of Physostigmine Against Soman Poisoning in Guinea Pigs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A47%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Scopolamine%20Augments%20the%20Efficacy%20of%20Physostigmine%20Against%20Soman%20Poisoning%20in%20Guinea%20Pigs&rft.jtitle=Pharmacology,%20biochemistry%20and%20behavior&rft.au=Philippens,%20Ingrid%20H.C.H.M&rft.date=2000&rft.volume=65&rft.issue=1&rft.spage=175&rft.epage=182&rft.pages=175-182&rft.issn=0091-3057&rft.eissn=1873-5177&rft.coden=PBBHAU&rft_id=info:doi/10.1016/S0091-3057(99)00171-9&rft_dat=%3Cproquest_cross%3E17519651%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17519651&rft_id=info:pmid/10638651&rft_els_id=S0091305799001719&rfr_iscdi=true |