Induction and Regulation of Matrix Metalloproteinase-12 by Cytokines and CD40 Signaling in Monocyte/Macrophages

Matrix metalloproteinase-12 (MMP-12) has been shown to play critical roles in atherogenesis. To determine the cellular mechanisms for control of MMP-12 expression, we studied the effects of several cytokines (GM-CSF, IL-1β, MCP-1) and CD40 ligand on MMP-12 expression in human monocyte/macrophages. U...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-03, Vol.269 (3), p.808-815
Hauptverfasser:	Wu, Lihua, Fan, Jianglin, Matsumoto, Shun-ichiro, Watanabe, Teruo
Format:	Artikel
Sprache:	eng
Schlagworte:	CD40 antigen CD40 Antigens - physiology CD40 Ligand CD40 signaling Chemokine CCL2 - pharmacology Cytokines - pharmacology Enzyme Induction Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - immunology GM-CSF Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Humans IL-1β interleukin 1b Interleukin-1 - pharmacology Kinetics macrophage Macrophages - enzymology Macrophages - immunology Matrix Metalloproteinase 12 MCP-1 Membrane Glycoproteins - pharmacology Metalloendopeptidases - biosynthesis Metalloendopeptidases - genetics MMP monocytes Monocytes - enzymology Monocytes - immunology Signal Transduction Tetradecanoylphorbol Acetate - pharmacology U937 Cells
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