Rat extracorporeal circulation model for evaluation of systemic immunotoxicity

We have applied a rat extracorporeal circulation (EC) model as an evaluation system for the immunotoxicity of medical devices in contact with the blood stream. Combining popular hemodialysis (HD) membranes [a non-biocompatible membrane, Cupurophane® (CUP), and more biocompatible membranes, Cu–ammoni...

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Veröffentlicht in:	Toxicology letters 2000-04, Vol.115 (1), p.63-70
Hauptverfasser:	Adachi, Tomoko, Mogi, Makio, Furuya, Mami, Kojima, Kohichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - toxicity Biological and medical sciences Complement C3 - metabolism Complement Hemolytic Activity Assay Equipment and Supplies - adverse effects Evaluation Studies as Topic Experimental and animal immunopathology. Animal models Extracorporeal Circulation Female Humans IgG Immunity Immunoglobulin G - metabolism Immunopathology Lymphocytes - immunology Medical sciences Membranes, Artificial Rats Rats, Sprague-Dawley Renal Dialysis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Toxicity Tests - methods Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
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