Evidence against a direct cytotoxic effect of alpha interferon and zidovudine in HTLV-I associated adult T cell leukemia/lymphoma

The combination of the anti-viral agents, zidovudine (AZT) and interferon-alpha (IFN), is a potent treatment of HTLV-I-associated adult T cell leukemia/lymphoma (ATL). In this study we investigate the possible mechanism of action of this combination by examining several cellular parameters including...

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Veröffentlicht in:	Leukemia 2000-04, Vol.14 (4), p.716-721
Hauptverfasser:	BAZARBACHI, A, NASR, R, DIANOUX, L, CHELBI-ALIX, M. K, DE THE, H, HERMINE, O, EL-SABBAN, M. E, MAHE, A, MAHIEUX, R, GESSAIN, A, DARWICHE, N, DBAIBO, G, KERSUAL, J, ZERMATI, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult T cell leukemia Aged Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Antiretroviral drugs Antiviral agents Apoptosis Apoptosis - drug effects Bcl-2 protein Biological and medical sciences Biomarkers, Tumor - analysis Cell culture Cell cycle Cell growth Cell proliferation Cell Survival - drug effects Combined Modality Therapy Cytotoxicity DNA, Neoplasm - analysis Dosage and administration Drug Synergism Drug therapy Drug therapy, Combination Female Genetic aspects Health aspects Hematologic and hematopoietic diseases Human T-lymphotropic virus 1 Human T-lymphotropic virus 1 - isolation & purification Humans HuT-102 cells Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Interferon Interferon alpha Interferon-alpha - pharmacology Interferon-alpha - therapeutic use Jurkat Cells - drug effects Leukemia Leukemia-Lymphoma, Adult T-Cell - drug therapy Leukemia-Lymphoma, Adult T-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes Lymphocytes T Lymphoma Medical sciences MT-2 cells Neoplastic Stem Cells - drug effects Remission Remission Induction T-Lymphocytes - drug effects Tumor Cells, Cultured - drug effects Zidovudine Zidovudine - pharmacology Zidovudine - therapeutic use α-Interferon
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