The expansion of murine bone marrow cells preincubated in hypoxia as an in vitro indicator of their marrow-repopulating ability

In liquid cultures of murine bone marrow cells stimulated with interleukin-3 and granulocyte/macrophage colony-stimulating factor, hypoxia (1% oxygen) induced a reversible block of hematopoiesis, maintaining the progenitors' expansion potential unreduced. Progenitors repopulating day-14 hypoxic...

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Veröffentlicht in:	Leukemia 2000-04, Vol.14 (4), p.735-739
Hauptverfasser:	CIPOLLESCHI, M. G, ROVIDA, E, IVANOVIC, Z, PRALORAN, V, OLIVOTTO, M, DELLO SBARBA, P
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antimetabolites - pharmacology Biological and medical sciences Bone marrow Bone Marrow Cells - cytology Bone marrow, stem cells transplantation. Graft versus host reaction Cell Hypoxia Cells, Cultured Colonies Colony-Forming Units Assay Colony-stimulating factor Cytokines Drug Resistance Fluorouracil - pharmacology Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Granulocytes Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hemopoiesis Hypoxia Interleukin 3 Leukemia Maintenance Medical sciences Mice Mice, Inbred CBA Progenitor cells Radiation Chimera Repopulation Stem cells Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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