Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines

Neurotoxic amphetamines cause damage to monoamine nerve terminals of the striatum by unknown mechanisms. Microglial activation contributes to the neuronal damage that accompanies injury, disease, and inflammation, but a role for these cells in amphetamine-induced neurotoxicity has received little at...

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Veröffentlicht in:	Neuroscience letters 2004-09, Vol.367 (3), p.349-354
Hauptverfasser:	Thomas, David M., Dowgiert, Jennifer, Geddes, Timothy J., Francescutti-Verbeem, Dina, Liu, Xiuli, Kuhn, Donald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - toxicity Analysis of Variance Animals Biological and medical sciences Blotting, Western - methods Cell Count - methods Corpus Striatum - cytology Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine Agents - toxicity Female Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - metabolism Immunohistochemistry - methods Lectins MDMA Methamphetamine Methamphetamine - pharmacology Mice Mice, Inbred C57BL Microglia Microglia - drug effects Microglia - physiology N-Methyl-3,4-methylenedioxyamphetamine - pharmacology Neurotoxicity p-Chloroamphetamine - pharmacology Striatum Vertebrates: nervous system and sense organs
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