High frequency of non-B subtypes in newly diagnosed HIV-1 infections in Switzerland
HIV-1 subtypes were determined in newly diagnosed residents of Switzerland. Blood was anonymously collected from patients with a first confirmed positive HIV-1 test result. Viral DNA from the env V3-V5 region was amplified by nested polymerase chain reaction (PCR) and screened for subtype B by heter...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 1999-10, Vol.22 (2), p.174-179 |
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| creator | BÖNI, J PYRA, H GROB, P BURCKHARDT, J. J ZWAHLEN, M SCHÜPBACH, J GEBHARDT, M PERRIN, L BÜRGISSER, P MATTER, L FIERZ, W ERB, P PIFFARETTI, J.-C MINDER, E |
| description | HIV-1 subtypes were determined in newly diagnosed residents of Switzerland. Blood was anonymously collected from patients with a first confirmed positive HIV-1 test result. Viral DNA from the env V3-V5 region was amplified by nested polymerase chain reaction (PCR) and screened for subtype B by heteroduplex mobility assay. All amplicons not identified as B were sequenced. From November 1996 to February 1998, 206 samples were analyzed. Main transmission risks were unprotected heterosexual (55.7%) or homosexual (27.1%) sexual contact or intravenous drug use (12.9%). Subtype B dominated in patients of Swiss, other European, American, or Asian citizenship; particularly high frequencies were found in homosexuals (97%) and drug users (94%). Non-B subtypes including A, C, D, E, F, G, H, a possible B/F recombinant, and a sequence related to J were present in 28.2% (95% confidence interval [CI], 22.9%-35.0%). Non-B were frequent in African citizens (95%), heterosexually infected individuals (44%), and women (43%). Heterosexually infected Swiss males harbored non-B strains in 18% and females in 33%. The results document a change in the epidemiology of newly diagnosed HIV-1 infections in Switzerland: predominance of heterosexual transmission and a high frequency of non-B subtypes. |
| doi_str_mv | 10.1097/00042560-199910010-00010 |
| format | Article |
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J ; ZWAHLEN, M ; SCHÜPBACH, J ; GEBHARDT, M ; PERRIN, L ; BÜRGISSER, P ; MATTER, L ; FIERZ, W ; ERB, P ; PIFFARETTI, J.-C ; MINDER, E</creator><creatorcontrib>BÖNI, J ; PYRA, H ; GROB, P ; BURCKHARDT, J. J ; ZWAHLEN, M ; SCHÜPBACH, J ; GEBHARDT, M ; PERRIN, L ; BÜRGISSER, P ; MATTER, L ; FIERZ, W ; ERB, P ; PIFFARETTI, J.-C ; MINDER, E</creatorcontrib><description>HIV-1 subtypes were determined in newly diagnosed residents of Switzerland. Blood was anonymously collected from patients with a first confirmed positive HIV-1 test result. Viral DNA from the env V3-V5 region was amplified by nested polymerase chain reaction (PCR) and screened for subtype B by heteroduplex mobility assay. All amplicons not identified as B were sequenced. From November 1996 to February 1998, 206 samples were analyzed. Main transmission risks were unprotected heterosexual (55.7%) or homosexual (27.1%) sexual contact or intravenous drug use (12.9%). Subtype B dominated in patients of Swiss, other European, American, or Asian citizenship; particularly high frequencies were found in homosexuals (97%) and drug users (94%). Non-B subtypes including A, C, D, E, F, G, H, a possible B/F recombinant, and a sequence related to J were present in 28.2% (95% confidence interval [CI], 22.9%-35.0%). Non-B were frequent in African citizens (95%), heterosexually infected individuals (44%), and women (43%). Heterosexually infected Swiss males harbored non-B strains in 18% and females in 33%. The results document a change in the epidemiology of newly diagnosed HIV-1 infections in Switzerland: predominance of heterosexual transmission and a high frequency of non-B subtypes.</description><identifier>ISSN: 1077-9450</identifier><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 2331-6993</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/00042560-199910010-00010</identifier><identifier>PMID: 10843532</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>New York, NY: Raven Press</publisher><subject>Adult ; Biological and medical sciences ; env gene ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Products, env - analysis ; Genetics ; Heterosexuality ; HIV ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV-1 - classification ; Homosexuality ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Prevalence ; Risk Factors ; Substance Abuse, Intravenous - complications ; Switzerland ; Switzerland - epidemiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Virology</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 1999-10, Vol.22 (2), p.174-179</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Oct 1, 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-47ee9c7361dacffc6128341a4b9b98ef3236855a574be704cb1d9bc7365d75ba3</citedby><cites>FETCH-LOGICAL-c448t-47ee9c7361dacffc6128341a4b9b98ef3236855a574be704cb1d9bc7365d75ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1185757$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10843532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BÖNI, J</creatorcontrib><creatorcontrib>PYRA, H</creatorcontrib><creatorcontrib>GROB, P</creatorcontrib><creatorcontrib>BURCKHARDT, J. J</creatorcontrib><creatorcontrib>ZWAHLEN, M</creatorcontrib><creatorcontrib>SCHÜPBACH, J</creatorcontrib><creatorcontrib>GEBHARDT, M</creatorcontrib><creatorcontrib>PERRIN, L</creatorcontrib><creatorcontrib>BÜRGISSER, P</creatorcontrib><creatorcontrib>MATTER, L</creatorcontrib><creatorcontrib>FIERZ, W</creatorcontrib><creatorcontrib>ERB, P</creatorcontrib><creatorcontrib>PIFFARETTI, J.-C</creatorcontrib><creatorcontrib>MINDER, E</creatorcontrib><title>High frequency of non-B subtypes in newly diagnosed HIV-1 infections in Switzerland</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>HIV-1 subtypes were determined in newly diagnosed residents of Switzerland. Blood was anonymously collected from patients with a first confirmed positive HIV-1 test result. Viral DNA from the env V3-V5 region was amplified by nested polymerase chain reaction (PCR) and screened for subtype B by heteroduplex mobility assay. All amplicons not identified as B were sequenced. From November 1996 to February 1998, 206 samples were analyzed. Main transmission risks were unprotected heterosexual (55.7%) or homosexual (27.1%) sexual contact or intravenous drug use (12.9%). Subtype B dominated in patients of Swiss, other European, American, or Asian citizenship; particularly high frequencies were found in homosexuals (97%) and drug users (94%). Non-B subtypes including A, C, D, E, F, G, H, a possible B/F recombinant, and a sequence related to J were present in 28.2% (95% confidence interval [CI], 22.9%-35.0%). Non-B were frequent in African citizens (95%), heterosexually infected individuals (44%), and women (43%). Heterosexually infected Swiss males harbored non-B strains in 18% and females in 33%. The results document a change in the epidemiology of newly diagnosed HIV-1 infections in Switzerland: predominance of heterosexual transmission and a high frequency of non-B subtypes.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>env gene</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Products, env - analysis</subject><subject>Genetics</subject><subject>Heterosexuality</subject><subject>HIV</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - classification</subject><subject>Homosexuality</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Substance Abuse, Intravenous - complications</subject><subject>Switzerland</subject><subject>Switzerland - epidemiology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Virology</subject><issn>1077-9450</issn><issn>1525-4135</issn><issn>2331-6993</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1rGzEQhkVpaNwkf6GIUnJTq1lJq9UxMUltMPTgJFeh1UruhrXWkXYx7q-P_NGm5DJzmOcdXh6EMNDvQJX8QSnlhSgpAaUUUAqU0P38gCYFY0BKpdhHNAEqJVFc0HP0OaXnTEjG6Cd0DrTiTLBigpazdvUb--heRhfsDvcehz6QW5zGethtXMJtwMFtux1uWrMKfXINns2fCOSDd3Zo-3Bgltt2-ONiZ0Jzic686ZK7Ou0L9Hh_9zCdkcWvn_PpzYJYzquBcOmcspKV0BjrvS2hqBgHw2tVq8p5VrCyEsIIyWsnKbc1NKreB0QjRW3YBbo-_t3EPtdPg163yboud3D9mDRIAVUBLINf34HP_RhD7qazrpJLXooMVUfIxj6l6LzexHZt4k4D1Xvr-q91_c-6PljP0S-n_2O9ds1_waPmDHw7ASZZ0_logm3TGweVkEKyVzYniHI</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>BÖNI, J</creator><creator>PYRA, H</creator><creator>GROB, P</creator><creator>BURCKHARDT, J. 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J ; ZWAHLEN, M ; SCHÜPBACH, J ; GEBHARDT, M ; PERRIN, L ; BÜRGISSER, P ; MATTER, L ; FIERZ, W ; ERB, P ; PIFFARETTI, J.-C ; MINDER, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-47ee9c7361dacffc6128341a4b9b98ef3236855a574be704cb1d9bc7365d75ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>env gene</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Products, env - analysis</topic><topic>Genetics</topic><topic>Heterosexuality</topic><topic>HIV</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - classification</topic><topic>Homosexuality</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Substance Abuse, Intravenous - complications</topic><topic>Switzerland</topic><topic>Switzerland - epidemiology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. 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J</au><au>ZWAHLEN, M</au><au>SCHÜPBACH, J</au><au>GEBHARDT, M</au><au>PERRIN, L</au><au>BÜRGISSER, P</au><au>MATTER, L</au><au>FIERZ, W</au><au>ERB, P</au><au>PIFFARETTI, J.-C</au><au>MINDER, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High frequency of non-B subtypes in newly diagnosed HIV-1 infections in Switzerland</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>22</volume><issue>2</issue><spage>174</spage><epage>179</epage><pages>174-179</pages><issn>1077-9450</issn><issn>1525-4135</issn><eissn>2331-6993</eissn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>HIV-1 subtypes were determined in newly diagnosed residents of Switzerland. Blood was anonymously collected from patients with a first confirmed positive HIV-1 test result. Viral DNA from the env V3-V5 region was amplified by nested polymerase chain reaction (PCR) and screened for subtype B by heteroduplex mobility assay. All amplicons not identified as B were sequenced. From November 1996 to February 1998, 206 samples were analyzed. Main transmission risks were unprotected heterosexual (55.7%) or homosexual (27.1%) sexual contact or intravenous drug use (12.9%). Subtype B dominated in patients of Swiss, other European, American, or Asian citizenship; particularly high frequencies were found in homosexuals (97%) and drug users (94%). Non-B subtypes including A, C, D, E, F, G, H, a possible B/F recombinant, and a sequence related to J were present in 28.2% (95% confidence interval [CI], 22.9%-35.0%). Non-B were frequent in African citizens (95%), heterosexually infected individuals (44%), and women (43%). Heterosexually infected Swiss males harbored non-B strains in 18% and females in 33%. The results document a change in the epidemiology of newly diagnosed HIV-1 infections in Switzerland: predominance of heterosexual transmission and a high frequency of non-B subtypes.</abstract><cop>New York, NY</cop><pub>Raven Press</pub><pmid>10843532</pmid><doi>10.1097/00042560-199910010-00010</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1077-9450 |
| ispartof | Journal of acquired immune deficiency syndromes (1999), 1999-10, Vol.22 (2), p.174-179 |
| issn | 1077-9450 1525-4135 2331-6993 1944-7884 |
| language | eng |
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| source | Freely Accessible Journals; MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences env gene Epidemiology Female Fundamental and applied biological sciences. Psychology Gene Products, env - analysis Genetics Heterosexuality HIV HIV Infections - epidemiology HIV Infections - virology HIV-1 - classification Homosexuality Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Prevalence Risk Factors Substance Abuse, Intravenous - complications Switzerland Switzerland - epidemiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology |
| title | High frequency of non-B subtypes in newly diagnosed HIV-1 infections in Switzerland |
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