New trichothecenes isolated from Holarrhena floribunda
Bioassay-guided fractionation of an extract of Holarrhena floribunda stem, has led to the isolation of the new trichothecenes, 8-dihydrotrichothecinol A (1), loukacinol A (2), and loukacinol B (3), and the known compounds, trichothecolone (4), trichothecin (5), trichothecinol A (6), rosenonolactone...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2000-01, Vol.63 (1), p.52-56 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Loukaci, A Kayser, O Bindseil, K.U Siems, K Frevert, J Abreu, P.M |
| description | Bioassay-guided fractionation of an extract of Holarrhena floribunda stem, has led to the isolation of the new trichothecenes, 8-dihydrotrichothecinol A (1), loukacinol A (2), and loukacinol B (3), and the known compounds, trichothecolone (4), trichothecin (5), trichothecinol A (6), rosenonolactone (7), 6beta-hydroxyrosenonolactone (8), and rosololactone (9). The structures were determined by spectral and chemical methods, and absolute configurations were established by a modified Horeau's method using HPLC. Compounds 1 and 6 exhibited significant cytotoxicity against several human tumor cell lines, whereas compound 8 showed moderate and weak antileishmanial activity toward extracellular and intracellular Leishmania donovani, respectively. |
| doi_str_mv | 10.1021/np990332l |
| format | Article |
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The structures were determined by spectral and chemical methods, and absolute configurations were established by a modified Horeau's method using HPLC. Compounds 1 and 6 exhibited significant cytotoxicity against several human tumor cell lines, whereas compound 8 showed moderate and weak antileishmanial activity toward extracellular and intracellular Leishmania donovani, respectively.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np990332l</identifier><identifier>PMID: 10650079</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>6beta-hydroxyrosenonolactone ; 8-Dihydrotrichothecinol A ; Animals ; antineoplastic agents ; antiprotozoal agents ; Biological and medical sciences ; chemical constituents of plants ; chemical structure ; cytotoxic compounds ; Drug Screening Assays, Antitumor ; General pharmacology ; Holarrhena floribunda ; Humans ; Leishmania donovani ; loukacinol A ; loukacinol B ; Medical sciences ; medicinal plants ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plants, Medicinal - chemistry ; rosenonalactone ; rosololactone ; spectral analysis ; Spectrum Analysis ; stems ; trichothecenes ; Trichothecenes - chemistry ; Trichothecenes - isolation & purification ; trichothecin ; trichothecinol a ; trichothecolone ; Tumor Cells, Cultured</subject><ispartof>Journal of natural products (Washington, D.C.), 2000-01, Vol.63 (1), p.52-56</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1038865$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10650079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Loukaci, A</creatorcontrib><creatorcontrib>Kayser, O</creatorcontrib><creatorcontrib>Bindseil, K.U</creatorcontrib><creatorcontrib>Siems, K</creatorcontrib><creatorcontrib>Frevert, J</creatorcontrib><creatorcontrib>Abreu, P.M</creatorcontrib><title>New trichothecenes isolated from Holarrhena floribunda</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Bioassay-guided fractionation of an extract of Holarrhena floribunda stem, has led to the isolation of the new trichothecenes, 8-dihydrotrichothecinol A (1), loukacinol A (2), and loukacinol B (3), and the known compounds, trichothecolone (4), trichothecin (5), trichothecinol A (6), rosenonolactone (7), 6beta-hydroxyrosenonolactone (8), and rosololactone (9). The structures were determined by spectral and chemical methods, and absolute configurations were established by a modified Horeau's method using HPLC. Compounds 1 and 6 exhibited significant cytotoxicity against several human tumor cell lines, whereas compound 8 showed moderate and weak antileishmanial activity toward extracellular and intracellular Leishmania donovani, respectively.</description><subject>6beta-hydroxyrosenonolactone</subject><subject>8-Dihydrotrichothecinol A</subject><subject>Animals</subject><subject>antineoplastic agents</subject><subject>antiprotozoal agents</subject><subject>Biological and medical sciences</subject><subject>chemical constituents of plants</subject><subject>chemical structure</subject><subject>cytotoxic compounds</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General pharmacology</subject><subject>Holarrhena floribunda</subject><subject>Humans</subject><subject>Leishmania donovani</subject><subject>loukacinol A</subject><subject>loukacinol B</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>rosenonalactone</subject><subject>rosololactone</subject><subject>spectral analysis</subject><subject>Spectrum Analysis</subject><subject>stems</subject><subject>trichothecenes</subject><subject>Trichothecenes - chemistry</subject><subject>Trichothecenes - isolation & purification</subject><subject>trichothecin</subject><subject>trichothecinol a</subject><subject>trichothecolone</subject><subject>Tumor Cells, Cultured</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNz01PwzAMBuAIgdj4OPAHoAfErWA3Tdoe0YANaQykbRcukZsmrNC1I-kE_HuKNhAn2_IjWy9jJwiXCBFe1assA86jaof1UUQQSojELusDSh7yVMY9duD9KwBwyMQ-6yFIAZBkfSYn5iNoXakXTbsw2tTGB6VvKmpNEVjXLINRNzi3MDUFtmpcma_rgo7YnqXKm-NtPWTzu9vZYBSOH4f3g-txaHkm2rBIhLFJYXKOGmSOXUOy4DZDoSPAXKdpGkuKc2NQxtrGRc41IWFBZHUq-CG72NxdueZ9bXyrlqXXpqqoNs3aK0wEJhmmHTzdwnW-NIVauXJJ7kv9Ju3A-RaQ11RZR7Uu_T_H01T-PAw3rPSt-fxbk3tTMuGJULOnqbqZTPHheThT486fbbylRtGL607Op100DlEWc0hi_g3dfXpj</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Loukaci, A</creator><creator>Kayser, O</creator><creator>Bindseil, K.U</creator><creator>Siems, K</creator><creator>Frevert, J</creator><creator>Abreu, P.M</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>M7N</scope></search><sort><creationdate>20000101</creationdate><title>New trichothecenes isolated from Holarrhena floribunda</title><author>Loukaci, A ; Kayser, O ; Bindseil, K.U ; Siems, K ; Frevert, J ; Abreu, P.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f395t-d75ef7deb31c06b1eb3a6d3f915c201bc88846a4bee164cf4db3ca1a1daafc853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>6beta-hydroxyrosenonolactone</topic><topic>8-Dihydrotrichothecinol A</topic><topic>Animals</topic><topic>antineoplastic agents</topic><topic>antiprotozoal agents</topic><topic>Biological and medical sciences</topic><topic>chemical constituents of plants</topic><topic>chemical structure</topic><topic>cytotoxic compounds</topic><topic>Drug Screening Assays, Antitumor</topic><topic>General pharmacology</topic><topic>Holarrhena floribunda</topic><topic>Humans</topic><topic>Leishmania donovani</topic><topic>loukacinol A</topic><topic>loukacinol B</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Structure</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>rosenonalactone</topic><topic>rosololactone</topic><topic>spectral analysis</topic><topic>Spectrum Analysis</topic><topic>stems</topic><topic>trichothecenes</topic><topic>Trichothecenes - chemistry</topic><topic>Trichothecenes - isolation & purification</topic><topic>trichothecin</topic><topic>trichothecinol a</topic><topic>trichothecolone</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loukaci, A</creatorcontrib><creatorcontrib>Kayser, O</creatorcontrib><creatorcontrib>Bindseil, K.U</creatorcontrib><creatorcontrib>Siems, K</creatorcontrib><creatorcontrib>Frevert, J</creatorcontrib><creatorcontrib>Abreu, P.M</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loukaci, A</au><au>Kayser, O</au><au>Bindseil, K.U</au><au>Siems, K</au><au>Frevert, J</au><au>Abreu, P.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New trichothecenes isolated from Holarrhena floribunda</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>63</volume><issue>1</issue><spage>52</spage><epage>56</epage><pages>52-56</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Bioassay-guided fractionation of an extract of Holarrhena floribunda stem, has led to the isolation of the new trichothecenes, 8-dihydrotrichothecinol A (1), loukacinol A (2), and loukacinol B (3), and the known compounds, trichothecolone (4), trichothecin (5), trichothecinol A (6), rosenonolactone (7), 6beta-hydroxyrosenonolactone (8), and rosololactone (9). The structures were determined by spectral and chemical methods, and absolute configurations were established by a modified Horeau's method using HPLC. Compounds 1 and 6 exhibited significant cytotoxicity against several human tumor cell lines, whereas compound 8 showed moderate and weak antileishmanial activity toward extracellular and intracellular Leishmania donovani, respectively.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>10650079</pmid><doi>10.1021/np990332l</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of natural products (Washington, D.C.), 2000-01, Vol.63 (1), p.52-56 |
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| subjects | 6beta-hydroxyrosenonolactone 8-Dihydrotrichothecinol A Animals antineoplastic agents antiprotozoal agents Biological and medical sciences chemical constituents of plants chemical structure cytotoxic compounds Drug Screening Assays, Antitumor General pharmacology Holarrhena floribunda Humans Leishmania donovani loukacinol A loukacinol B Medical sciences medicinal plants Mice Mice, Inbred C57BL Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry rosenonalactone rosololactone spectral analysis Spectrum Analysis stems trichothecenes Trichothecenes - chemistry Trichothecenes - isolation & purification trichothecin trichothecinol a trichothecolone Tumor Cells, Cultured |
| title | New trichothecenes isolated from Holarrhena floribunda |
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